{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:16:57Z","timestamp":1790252217382,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>\n                    Recent studies have highlighted a possible role for gut microbiota in modulating Alzheimer\u2019s disease pathology, particularly through the actions of gut-derived metabolites and their influence on the immune system. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Chandra et al. reveal that circulating levels of the gut microbiota\u2013derived metabolite propionate affected amyloid burden and glial activation in a mouse model of A\u03b2 amyloidosis. The study also identifies a mechanism for the therapeutic benefit of propionate supplementation, showing that propionate lowered peripheral IL-17 and suppressed Th17 cell activity. These results support the idea of therapeutic targeting of the gut\/brain\/immune axis, particularly via modulation of Th17 responses, and suggest translational strategies involving microbiome-based or immunological interventions for dementia prevention and treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci194443","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:00:34Z","timestamp":1751292034000},"source":"Crossref","is-referenced-by-count":3,"title":["Thwarting amyloidosis: IL-17 as a disease modifier along the gut\/brain axis"],"prefix":"10.1172","volume":"135","author":[{"given":"Wade K.","family":"Self","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-0856","authenticated-orcid":true,"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02505-2"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30028"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/srep41802"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13601-y"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo2984"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111572"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.10.010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59826"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180826"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.035"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01497-z"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0059-z"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182386"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00635-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.10.1221"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4030"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03734-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.01.013"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11047-w"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03122-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109574"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01213"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318200d78d"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52283"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-220060"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/194443\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:17:25Z","timestamp":1779211045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/194443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":26,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,5,13]]},"published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["10.1172\/JCI194443"],"URL":"https:\/\/doi.org\/10.1172\/jci194443","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"article-number":"e194443"}}