{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:27:57Z","timestamp":1790440077542,"version":"4.1.0"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"crossref","award":["SKGJ-MED-017"],"award-info":[{"award-number":["SKGJ-MED-017"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["295844,324302,295910"],"award-info":[{"award-number":["295844,324302,295910"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:p>Crypt hyperplasia is a key feature of celiac disease (CeD) and several other small intestinal inflammatory conditions. Analysis of the gut epithelial crypt zone by mass spectrometry\u2013based tissue proteomics revealed a strong IFN-\u03b3 signal in active CeD. This signal, hallmarked by increased expression of MHC molecules, was paralleled by diminished expression of proteins associated with fatty acid metabolism. Crypt hyperplasia and the same proteomic changes were observed in WT mice administered IFN-\u03b3. In mice with conditional KO of the IFN-\u03b3 receptor in gut epithelial cells, these signature morphological and proteomic changes were not induced with IFN-\u03b3 administration. IFN-\u03b3 was thus a driver of crypt hyperplasia in CeD by acting directly on crypt epithelial cells. The results are relevant to other enteropathies with involvement of IFN-\u03b3.<\/jats:p>","DOI":"10.1172\/jci194858","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:00:46Z","timestamp":1755619246000},"source":"Crossref","is-referenced-by-count":11,"title":["IFN-\u03b3 is a direct driver of crypt hyperplasia in celiac disease"],"prefix":"10.1172","volume":"135","author":[{"given":"Jorunn","family":"Stamnaes","sequence":"first","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Proteomics Core Facility, University of Oslo and Oslo University Hospital, Oslo, Norway."},{"name":"Department of Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stray","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fleur","family":"du Pr\u00e9","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise F.","family":"Risnes","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Gastroenterology, Oslo University Hospital-Rikshospitalet, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa E.","family":"Dewan","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakeer","family":"Shaik","sequence":"additional","affiliation":[{"name":"Department of Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stensland","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, University of Oslo and Oslo University Hospital, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-5545","authenticated-orcid":true,"given":"Knut E.A.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Gastroenterology, Oslo University Hospital-Rikshospitalet, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-704X","authenticated-orcid":true,"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Department of Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.2.185"},{"key":"B2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34805-X"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(64)80102-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00794-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(60)80143-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.9.701"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.321"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-032634"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.187"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0016-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0403-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.6.766"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70134-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01195.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35355"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.017"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01867-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.020"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.018"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.039"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.03.042"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1341"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90342-X"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2792"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01536-4"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08061-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.03.006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.749"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.008"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.06.002"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.050"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<730::AID-IMMU730>3.0.CO;2-U"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121886"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02146-2"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035345"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.07.008"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1987.tb02290.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1988.tb02076.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109043634"},{"issue":"5","key":"B44","first-page":"923","article-title":"Expression and function of class II antigens on gastric carcinoma cells and gastric epithelia: differential expression of DR, DQ, and DP antigens","volume":"79","author":"Sakai","year":"1987","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"B45","first-page":"489","article-title":"Human retinal pigment epithelial cells differentially express MHC class II (HLA, DP, DR and DQ) antigens in response to in vitro stimulation with lymphokine or purified IFN-gamma","volume":"73","author":"Liversidge","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.013"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay8556"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55227-5"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41683-y"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003526"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.07.010"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2508"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130753"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1136\/gut.20.1.55"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.10.812"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1309\/5ADNAR4VN11TTKQ6"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.048"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.04.001"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107565"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.08.007"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.016"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0278-0"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003181"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07716-2"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300910"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204935200"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287662"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4256"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR120.002048"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)00110-C"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1011"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/194858\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:10:23Z","timestamp":1779210623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/194858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":77,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10,15]]},"published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1172\/JCI194858"],"URL":"https:\/\/doi.org\/10.1172\/jci194858","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"article-number":"e194858"}}