{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:06:41Z","timestamp":1779214001619,"version":"3.51.4"},"reference-count":22,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    Cellular susceptibility to HIV is associated with integrin \u03b14\u03b27, a mucosal homing receptor involved with trafficking HIV target cells to sites of HIV replication. However, studies investigating preinfection \u03b14\u03b27 expression as a predictor of HIV outcomes have yielded inconsistent findings, raising questions about the role of \u03b14\u03b27 in HIV acquisition across populations. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Machmach et al. assessed PBMCs collected before HIV infection and found higher \u03b14\u03b27 expression on memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and invariant NK T (iNKT) cells in individuals who went on to acquire HIV. Here, we consider possible explanations that may underlie discrepancies among studies and suggest that \u03b14\u03b27 should be considered as part of a multifactorial profile for determining HIV risk. While unlikely to serve as a target for HIV prevention or therapy, \u03b14\u03b27-directed interventions may offer adjunctive benefits in preserving or improving mucosal immunity.\n                  <\/jats:p>","DOI":"10.1172\/jci195258","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T23:07:57Z","timestamp":1754348877000},"source":"Crossref","is-referenced-by-count":3,"title":["Integrin \u03b14\u03b27 as a predictor of HIV acquisition: one thread in a complex tapestry"],"prefix":"10.1172","volume":"135","author":[{"given":"Tosin E.","family":"Omole","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada."},{"name":"Vaccine and Infectious Disease Organization (VIDO), Saskatoon, Saskatchewan, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle R.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada."},{"name":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa."},{"name":"Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0381-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147512"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1276"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav6695"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw7765"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa497"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13254"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4MR0120-208R"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0183-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011501117"},{"issue":"15","key":"B12","doi-asserted-by":"crossref","DOI":"10.1172\/JCI187992","article-title":"NK cell activation and CD4+ T cell \u03b14\u03b27 expression are associated with susceptibility to HIV-1","volume":"135","author":"Machmach","year":"2025","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam6354"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103102"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae638"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-018-0382-3"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143895"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315586970"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.184491"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adg7549"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau4711"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2110665"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/195258\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:15:48Z","timestamp":1779210948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/195258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":22,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,6,12]]},"published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1172\/JCI195258"],"URL":"https:\/\/doi.org\/10.1172\/jci195258","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"article-number":"e195258"}}