{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:18:43Z","timestamp":1789676323538,"version":"4.0.1"},"reference-count":65,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["R01CA164225"],"award-info":[{"award-number":["R01CA164225"]}]},{"name":"National Cancer Institute","award":["R01CA223804"],"award-info":[{"award-number":["R01CA223804"]}]},{"name":"National Cancer Institute","award":["R21CA258618"],"award-info":[{"award-number":["R21CA258618"]}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["RSG-18-045-01-LIB"],"award-info":[{"award-number":["RSG-18-045-01-LIB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Defense CDMRP","award":["ME210229"],"award-info":[{"award-number":["ME210229"]}]},{"name":"National Cancer Institute","award":["F31CA257276"],"award-info":[{"award-number":["F31CA257276"]}]},{"name":"Department of Defense CDMRP","award":["BC240100"],"award-info":[{"award-number":["BC240100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:p>\n                    V-domain immunoglobulin suppressor of T cell activation (VISTA) is an immune checkpoint protein that impairs antitumor T cell responses. While broadly expressed on myeloid cells and T cells, the specific contribution of T cell\u2013intrinsic VISTA to antitumor immunity remains undefined. This study investigated the phenotypic and functional consequences of T cell\u2013specific VISTA deletion in tumor-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Single-cell transcriptomic analysis, TCR repertoire profiling, and flow cytometry revealed that loss of T cell\u2013intrinsic VISTA enhanced early priming and short-term expansion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, yet this initial advantage failed to confer durable tumor control. Persistent dysfunction in VISTA-deficient T cells was in part driven by\n                    <jats:italic>trans<\/jats:italic>\n                    -VISTA on myeloid cells, while CTLA-4 upregulation further constrained T cell responses. T cell\u2013intrinsic VISTA deficiency cooperated with CTLA-4 blockade to improve T cell survival and broaden TCR repertoire diversity, resulting in more robust tumor regression than CTLA-4 inhibition alone. A transcriptional signature enriched in VISTA-deficient cytotoxic T cells correlated with favorable outcomes in cancer patients treated with existing immune checkpoint inhibitors. These findings collectively define T cell\u2013intrinsic mechanisms by which VISTA enforces T cell dysfunction and underscore its potential as both a therapeutic target and a biomarker of resistance to current immunotherapies.\n                  <\/jats:p>","DOI":"10.1172\/jci195668","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:00:52Z","timestamp":1773597652000},"source":"Crossref","is-referenced-by-count":1,"title":["T cell\u2013intrinsic VISTA expression promotes resistance to CTLA-4 blockade by restricting CD8+ T cell responses"],"prefix":"10.1172","volume":"136","author":[{"given":"Cassandra","family":"Gilmour","sequence":"first","affiliation":[{"name":"Department of Translational Hematology & Oncology Research,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"DeLaney","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology & Oncology 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