{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:06:42Z","timestamp":1779214002752,"version":"3.51.4"},"reference-count":15,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    Over the last decade, there have been multiple outbreaks of enterovirus D68 (EV-D68) disease and associated cases of acute flaccid myelitis (AFM). The underlying cause of EV-D68\u2013induced AFM is contentious; whether spinal cord motor neurons are damaged by direct viral infection, infiltration of immune cells, or a combination of both is not clear. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Woods Acevedo and coworkers used a neonatal WT mouse model of EV-D68 infection to attribute paralytic disease to immune cell infiltration into the spinal cord. The results of their work in cytokine-knockout or immune cell\u2013depleted animals effectively argue that immunopathogenesis plays an integral role in EV-D68\u2013induced AFM.\n                  <\/jats:p>","DOI":"10.1172\/jci195839","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T23:07:57Z","timestamp":1754348877000},"source":"Crossref","is-referenced-by-count":3,"title":["EV-D68 neurological disease: tipping the scales toward immunopathogenesis"],"prefix":"10.1172","volume":"135","author":[{"given":"Peter W.","family":"Krug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2024.1328457"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9081758"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02370-19"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2118155"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.5858\/2010-0174-CR.1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00833-22"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI188495"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/v12080867"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix468"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-091319-083608"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010515"},{"key":"B12","doi-asserted-by":"crossref","unstructured":"Fall A, et al. Enhanced genomic surveillance of enteroviruses reveals a surge in enterovirus D68 cases in the Johns Hopkins health system, Maryland, 2024 [published online June 10, 2025]. J Clin Microbiol. https:\/\/doi.org\/10.1128\/jcm.00469-25","DOI":"10.1128\/jcm.00469-25"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01058-23"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00227-22"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03906-24"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/195839\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:15:28Z","timestamp":1779210928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/195839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":15,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,6,12]]},"published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1172\/JCI195839"],"URL":"https:\/\/doi.org\/10.1172\/jci195839","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"article-number":"e195839"}}