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However, in antibody-mediated autoimmune diseases occurring without vascular damage, neutrophils infiltrate tissues and contribute to pathology. Here, we investigated whether the dependence of neutrophils on platelets is conserved in the context of antibody-driven inflammation. Using human cells from individuals with rheumatoid arthritis and a microfluidic system mimicking physiological shear over IgG-containing immune complexes, we demonstrate that despite expressing Fc receptors, neutrophils required platelets to stably adhere to immune complexes under flow. Platelet Fc\u03b3 receptor 2a (Fc\u03b3RIIA) binding was critical for resisting shear stress, while neutrophils used Fc\u03b3RIIA and Fc\u03b3RIIIB for immune complex recognition. Platelet P-selectin binding to neutrophil P-selectin glycoprotein ligand 1 (PSGL-1) was essential for recruitment, whereas macrophage-1 antigen (Mac-1) was dispensable. In a mouse model of autoantibody-mediated arthritis, intravital imaging confirmed that neutrophil recruitment relied on PSGL-1. Importantly, expression of Fc\u03b3RIIA aggravated arthritis, and blockade of PSGL-1, but not Mac-1, in these mice abrogated both the platelet and neutrophil interactions and disease. These findings identify key molecular interactions in platelet-neutrophil cooperation and reveal that platelets are essential enablers of FcR-mediated neutrophil adhesion in antibody-driven inflammation.<\/jats:p>","DOI":"10.1172\/jci195987","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:00:31Z","timestamp":1764694831000},"source":"Crossref","is-referenced-by-count":3,"title":["Immobilized IgG-containing immune complexes require platelets to recruit neutrophils during inflammation"],"prefix":"10.1172","volume":"136","author":[{"given":"Marie","family":"Bellio","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de l\u2019Universit\u00e9 Laval, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."},{"name":"Centre de Recherche ARThrite \u2013 Arthrite, Recherche, Traitements, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."},{"name":"Axe maladies infectieuses et immunitaires du Centre de recherche du 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