{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:10:37Z","timestamp":1779210637129,"version":"3.51.4"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["U19AI181729"],"award-info":[{"award-number":["U19AI181729"]}]},{"name":"NIH","award":["R01DK119445"],"award-info":[{"award-number":["R01DK119445"]}]},{"name":"NIH","award":["R01DE030530"],"award-info":[{"award-number":["R01DE030530"]}]},{"name":"NIH","award":["R01AI143894"],"award-info":[{"award-number":["R01AI143894"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,16]]},"abstract":"<jats:p>\n                    Type 1 diabetes mellitus (T1D) is a chronic disease caused by an unremitting autoimmune attack on pancreatic \u03b2 cells. This autoimmune chronicity is mediated by stem-like progenitor CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells that continually repopulate the pool of \u03b2 cell\u2013specific cytolytic effectors. Factors governing the conversion of progenitors to effectors, however, remain unclear. T1D has been linked to a chromosomal region (Xp13-p11) that contains the epigenetic regulator UTX, which suggests a key role for UTX in T1D pathogenesis. Here, we show that T cell\u2013specific UTX deletion in NOD mice protects against T1D development. In T cells of NOD mice and patients with T1D, UTX ablation resulted in the accumulation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    progenitor cells with a concomitant decrease of effector cells, suggesting a key role for UTX in poising progenitors for transition to effectors. Mechanistically, UTX\u2019s role in T1D was independent of its inherent histone demethylase activity but instead relied on binding with transcription factors (TCF1 and STAT3) to coregulate genes important in the maintenance and differentiation of progenitor CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Together, these findings identify a critical role for UTX in T1D and the UTX:TCF1:STAT3 complex as a therapeutic target for terminating the long-lived autoimmune response.\n                  <\/jats:p>","DOI":"10.1172\/jci196325","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T17:00:26Z","timestamp":1765904426000},"source":"Crossref","is-referenced-by-count":0,"title":["UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes"],"prefix":"10.1172","volume":"136","author":[{"given":"Ho-Chung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison F.","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of 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