{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:09Z","timestamp":1791081969862,"version":"4.1.0"},"reference-count":14,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>\n                    The numbers of insulin-producing \u03b2 cells in the pancreas are reduced in people with type 1 or type 2 diabetes, prompting efforts to replace these missing or lost \u03b2 cells through transplant or regenerative medicine approaches. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Wortham et al. describe a function for the deacetylase enzyme sirtuin 2 (SIRT2) in a novel pathway that acts as a brake on \u03b2 cell proliferation. They show that inhibiting SIRT2 through pharmacologic or genetic approaches can induce human and mouse \u03b2 cells to reenter a proliferative cell cycle. A surprising observation that remains unexplained is that the main targets of SIRT2 are mitochondrial oxidative phosphorylation (OxPhos) enzymes. It also remains unknown if and how these unanticipated acetylated OxPhos targets lead to cell-cycle entry. SIRT2 inhibitors will be a welcome addition to the growing repertoire of human \u03b2 cell\u2013regenerative drugs.\n                  <\/jats:p>","DOI":"10.1172\/jci197142","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T18:01:01Z","timestamp":1759255261000},"source":"Crossref","is-referenced-by-count":2,"title":["SIRT2 puts the brakes on human \u03b2 cell proliferation: therapeutic opportunities and next challenges"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-0767","authenticated-orcid":true,"given":"Liora S.","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-9223","authenticated-orcid":true,"given":"Donald K.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-5959","authenticated-orcid":true,"given":"Andrew F.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"issue":"19","key":"B1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI187020","article-title":"et al. The protein deacetylase SIRT2 exerts metabolic control over adaptive \u03b2 cell proliferation","volume":"135","author":"Wortham","year":"2025","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0036"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00154"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.178"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.04.002"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3820"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1331"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111904"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12475"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.671946"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.023"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.031"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/197142\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:11:50Z","timestamp":1779210710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/197142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":14,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1172\/JCI197142"],"URL":"https:\/\/doi.org\/10.1172\/jci197142","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"e197142"}}