{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:35:08Z","timestamp":1790861708679,"version":"4.1.0"},"reference-count":90,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI167847,AI178159,AI114543,GM134880,NS122174,NS103212,AI125446,AI127481,167058,T32AI007260,T32CA078586,F32AI174382,T32GM139776"],"award-info":[{"award-number":["AI167847,AI178159,AI114543,GM134880,NS122174,NS103212,AI125446,AI127481,167058,T32AI007260,T32CA078586,F32AI174382,T32GM139776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HHMI Hanna H. Gray Fellow Program","award":["01"],"award-info":[{"award-number":["01"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K99AI190129-"],"award-info":[{"award-number":["K99AI190129-"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:p>\n                    Primary and metastatic brain tumors exhibit resistance to immunotherapies that demonstrate efficacy in peripheral cancer settings. While many immunotherapies aim to enhance CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and functionality in established tumors, identification of neoantigens support emerging immunopreventative tactics against brain cancer. Functionally potent tissue-resident memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) can be generated in the brain following peripheral infection or vaccination. However, the ability of brain T\n                    <jats:sub>RM<\/jats:sub>\n                    to prevent intracranial malignancy remains unknown. Here, mice were seeded with tumor-specific or bystander brain T\n                    <jats:sub>RM<\/jats:sub>\n                    via peripheral infection prior to depletion of circulating memory T cells (T\n                    <jats:sub>CIRCM<\/jats:sub>\n                    ) and subsequent brain tumor challenge. Tumor-specific brain T\n                    <jats:sub>RM<\/jats:sub>\n                    durably protected mice against intracranial malignancy even in the absence T\n                    <jats:sub>CIRCM<\/jats:sub>\n                    . These brain T\n                    <jats:sub>RM<\/jats:sub>\n                    persisted in tumor-surviving mice and protected against a second antigen-matched challenge. Importantly, a translationally-relevant mRNA-lipid nanoparticle (LNP) vaccine phenocopied peripheral infection-induced outcomes, generating functional brain T\n                    <jats:sub>RM<\/jats:sub>\n                    that controlled tumor growth. Altogether, this work points to the utility of brain T\n                    <jats:sub>RM<\/jats:sub>\n                    in cancer immunoprevention, supporting the development of antitumor mRNA-LNP vaccines to bolster brain immunity.\n                  <\/jats:p>","DOI":"10.1172\/jci197812","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:00:47Z","timestamp":1776189647000},"source":"Crossref","is-referenced-by-count":2,"title":["Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy"],"prefix":"10.1172","volume":"136","author":[{"given":"Madison R.","family":"Mix","sequence":"first","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Medical Scientist Training Program, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie M.","family":"Sievers","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Hassert","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan Kumar","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"},{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lecia L.","family":"Pewe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"},{"name":"Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cori E.","family":"Fain","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Heidarian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"},{"name":"Experimental Pathology Graduate Program, Carver College of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Hancox","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahaana A.","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Medical Scientist Training Program, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry G.","family":"Beltz","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin S.","family":"Carter","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"},{"name":"Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine,"},{"name":"Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah S.","family":"Butler","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"},{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliasger K.","family":"Salem","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"},{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P.","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Medical Scientist Training Program, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"},{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine,"},{"name":"Experimental Pathology Graduate Program, Carver College of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-2802","authenticated-orcid":true,"given":"John T.","family":"Harty","sequence":"additional","affiliation":[{"name":"Department of Pathology, Carver College of Medicine,"},{"name":"Medical Scientist Training Program, Carver College of Medicine,"},{"name":"Interdisciplinary Graduate Program in Immunology, Carver College of Medicine,"},{"name":"Experimental Pathology Graduate Program, Carver College of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1912-x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa343"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0135-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav0492"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142290"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.049"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac099"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02392-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.5370"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa0984"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00545-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.10.001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102454"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-03125-w"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07053-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb8786"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.019"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2515-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13710"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.043"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115960"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053214"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2568"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0711-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.005"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2400295"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115247"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2022.11.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08534-1"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add5976"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.06.017"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300049"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00884-8"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06063-y"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.06.019"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-025-01163-y"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0812-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6346"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15221"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1442163"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo2523"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add3075"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01562-6"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI195673"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08508-4"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231144"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01281-z"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nm1257"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.005"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0055-y"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-011-0203-y"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714089115"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1402578"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501071"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01004-1"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05626-9"},{"key":"B60","first-page":"579","article-title":"Intracranial metastases from systemic cancer","volume":"19","author":"Posner","year":"1978","journal-title":"Adv Neurol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02276-w"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.05.009"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00526-x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03324-6"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4161\/onci.27529"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0263-6"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8497-8503.1997"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1551::AID-CNCR19>3.0.CO;2-Z"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16596-9"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03037-x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.037"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2474"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ads1328"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.983000"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20241454"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105543"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174431"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08669-w"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00850-X"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00902-1"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104963"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.198069"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.773264"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4633"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67099-2"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.003"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02882-x"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1454370"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.015"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03152-x"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/197812\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:38:12Z","timestamp":1779208692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/197812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":90,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4,15]]},"published-print":{"date-parts":[[2026,4,15]]}},"alternative-id":["10.1172\/JCI197812"],"URL":"https:\/\/doi.org\/10.1172\/jci197812","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"article-number":"e197812"}}