{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:35:13Z","timestamp":1787726113884,"version":"build-2784847793"},"reference-count":28,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>\n                    Uniform radiation therapy (RT) de-escalation in HPV\n                    <jats:sup>+<\/jats:sup>\n                    oropharyngeal squamous cell carcinoma (OPSCC) has underperformed in clinical trials, likely due to underlying genomic heterogeneity. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Ho et al. evaluated genomic adjusted radiation dose (GARD), which integrates tumor gene expression with RT dose to estimate biological effect. In 191 locoregionally advanced HPV\n                    <jats:sup>+<\/jats:sup>\n                    OPSCC patients treated with definitive RT with or without chemotherapy, GARD values varied widely, despite uniform dose delivery, and independently predicted overall survival. These data support a genomically informed framework specific for HPV\n                    <jats:sup>+<\/jats:sup>\n                    OPSCC patients via GARD for guiding radiation dose de-escalation strategies.\n                  <\/jats:p>","DOI":"10.1172\/jci198351","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T18:01:01Z","timestamp":1759255261000},"source":"Crossref","is-referenced-by-count":1,"title":["Genomic adjusted radiation dose stratifies radiotherapy dosing based on tumor-specific sensitivity in HPV+ oropharyngeal cancer"],"prefix":"10.1172","volume":"135","author":[{"given":"Sandip K.","family":"Rath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30802-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26687"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.41538"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00281-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00560-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03128"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.08.014"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2025.01.004"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6416"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.01.005"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.07.1155"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI194073"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30648-9"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0891"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.014"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.05.056"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00553-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26515"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00347-8"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-023-02328-y"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-72818-w"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.6998"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31999-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01308"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/198351\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:11:43Z","timestamp":1779210703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/198351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":28,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1172\/JCI198351"],"URL":"https:\/\/doi.org\/10.1172\/jci198351","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"e198351"}}