{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:06:12Z","timestamp":1779213972107,"version":"3.51.4"},"reference-count":24,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:p>\n                    Neutrophils are key drivers of inflammation in Sweet syndrome (SS), a rare inflammatory skin disorder, but how they remain persistently activated in SS skin lesions has been unclear. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Huang, Sati, and colleagues applied single-cell RNA-Seq and immunofluorescence to identify a subset of neutrophils in SS skin that display antigen-presenting cell\u2013like (APC-like) features. The authors showed that when neutrophils interacted with keratinocytes, their lifespan was markedly extended, and they expressed MHC class II via activation of the serum amyloid A1\/formyl peptide receptor 2 (SAA1\/FPR2) signaling pathway. This, in turn, enabled T cell activation and sustained self-perpetuating inflammatory loops. These findings reveal a previously unrecognized keratinocyte-neutrophil circuit in SS and point to the SAA1\/FPR2 axis as a potential target for more precise, mechanism-based therapy.\n                  <\/jats:p>","DOI":"10.1172\/jci198494","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T19:53:39Z","timestamp":1760471619000},"source":"Crossref","is-referenced-by-count":0,"title":["Keratinocyte-neutrophil interactions revealed as targetable drivers of sustained inflammation in Sweet syndrome"],"prefix":"10.1172","volume":"135","author":[{"given":"Umi","family":"Tahara","sequence":"first","affiliation":[{"name":"Department of Dermatology, Keio University School of Medicine, Tokyo, Japan."},{"name":"Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Amagai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Keio University School of Medicine, Tokyo, Japan."},{"name":"Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1964.tb14541.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70022"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049722"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70266-X"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.5.570"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000371879"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162137"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14916"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12394"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI193566"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200154"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023444"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.005"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221866"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03723-x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00657.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.616"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12989"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04201.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2372-18"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14988"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00414"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.4342"},{"key":"B24","article-title":"Positionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet syndrome","author":"Cavagnero","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/198494\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:10:36Z","timestamp":1779210636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/198494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":24,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10,15]]},"published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1172\/JCI198494"],"URL":"https:\/\/doi.org\/10.1172\/jci198494","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"article-number":"e198494"}}