{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:37Z","timestamp":1792787617484,"version":"4.5.0"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research","award":["20009360,FBD-181475"],"award-info":[{"award-number":["20009360,FBD-181475"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>\n                    Interferon lambda (IFN-\u03bb) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal delivery of IFN-\u03bb abrogates the herpes simplex virus type 2\u2013induced (HSV-2-induced) vaginal tissue pathology observed in the absence of type I IFN signaling, through drastically inhibiting IL-6 production. At the same time, we demonstrated that IFN-\u03bb rescued local production of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013dependent IFN-\u03b3, which is essential for protection against the development of toxic megacolon following genital HSV-2 infection. Mechanistically, we found that IFN-\u03bb enhances the differentiation of CCR2\n                    <jats:sup>+<\/jats:sup>\n                    Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    cells into monocyte-derived antigen-presenting cells, thereby boosting T cell responses. In vivo depletion of CCR2\n                    <jats:sup>+<\/jats:sup>\n                    cells abrogated this phenomenon. Together, these findings suggest that IFN-\u03bb orchestrates a potent antiviral response, inhibiting hyperinflammatory responses while selectively augmenting effector T cell function. This study positions IFN-\u03bb as a promising therapeutic candidate for enhancing local antiviral immunity and offers new insights into the regulation of immune responses in the context of mucosal viral infections.\n                  <\/jats:p>","DOI":"10.1172\/jci198863","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:54:47Z","timestamp":1792004087000},"source":"Crossref","is-referenced-by-count":1,"title":["Interferon-\u03bb inhibits immunopathology and boosts T cell\u2013mediated immunity in a mouse model of mucosal viral infection"],"prefix":"10.1172","volume":"136","author":[{"given":"Emily","family":"Feng","sequence":"first","affiliation":[{"name":"McMaster Immunology Research Centre, Department of Medicine and"},{"name":"Michael G. 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