{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:53:58Z","timestamp":1781463238482,"version":"3.54.1"},"reference-count":60,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2022YFA1304003"],"award-info":[{"award-number":["2022YFA1304003"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32470970,81871305,82273463,32370731"],"award-info":[{"award-number":["32470970,81871305,82273463,32370731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Key Healthcare Projects of Xiamen City","award":["3502Z20234008"],"award-info":[{"award-number":["3502Z20234008"]}]},{"name":"The Scientific Research Foundation of State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","award":["2023XAKJ0101027,2025XAKJ0102016"],"award-info":[{"award-number":["2023XAKJ0101027,2025XAKJ0102016"]}]},{"name":"The Fundamental Research Funds for the Central Universities","award":["20720210113,20720220003"],"award-info":[{"award-number":["20720210113,20720220003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Type 1 conventional dendritic cells (cDC1s) play an integral role in mediating immune responses and maintaining homeostasis, yet the molecular mechanisms underlying their functions remain poorly understood. In this study, we identified dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) as a key kinase that responded to TLR and growth factor stimulation and acted as an essential regulator of cDC1 function. Genetic ablation of\n                    <jats:italic>Dyrk1a<\/jats:italic>\n                    specifically in cDC1s impaired antitumor immunity and accelerated tumor progression in murine models. Mechanistically, DYRK1A mediated the phosphorylation of the mTOR complex 1 (mTORC1) inhibitor TSC2 at serine 540, triggering the degradation of TSC2 and promoting mTORC1 signaling in cDC1s. Notably,\n                    <jats:italic>Tsc2<\/jats:italic>\n                    deletion in\n                    <jats:italic>Dyrk1a<\/jats:italic>\n                    -deficient cDC1s remarkably restored their antitumor immune functions. Furthermore, DYRK1A-mediated mTORC1 signaling in cDC1s positively correlated with effector T cell responses across multiple human cancers. Our findings highlight a critical role for the DYRK1A\/TSC2\/mTORC1 signaling pathway in regulating cDC1 functions in antitumor immunity, offering potential strategies to improve cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1172\/jci199108","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:00:43Z","timestamp":1776960043000},"source":"Crossref","is-referenced-by-count":0,"title":["DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation"],"prefix":"10.1172","volume":"136","author":[{"given":"Hongjiao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Xiamen Key Laboratory of Genetic Testing, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwen","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Affiliated Hospital of Hebei University, Clinical Medical College, Hebei University, Baoding, Hebei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangnan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qin","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Affiliated Hospital of Hebei University, Clinical Medical College, Hebei University, Baoding, Hebei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Du","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengming","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-7060","authenticated-orcid":true,"given":"Chun-Jung","family":"Ko","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-1000","authenticated-orcid":true,"given":"Jian-Hong","family":"Shi","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Affiliated Hospital of Hebei University, Clinical Medical College, Hebei University, Baoding, Hebei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Xiamen Key Laboratory of Genetic Testing, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuliang","family":"Jie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Department of Oncology, Xiang\u2019an Hospital of Xiamen University, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China."},{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.09.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0210-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.05.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074929"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.04.016"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00859-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02345-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000474"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121103"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074950"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161524"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0812397"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.008"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105323118"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100311-102839"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1307"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32419"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0636"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02245-6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1159\/000472398"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90286-4"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.09.009"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150002"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4161\/cc.29104"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.12.026"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.021"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.253"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49611-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135937"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011247"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37205-5"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.035"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2020"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111032"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-439786"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2155"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051106"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3196"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1735556100"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002790"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.32"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.06.008"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88318"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nri3198"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157535"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1753"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adg7995"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.08.009"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0916-x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58289-1"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1685"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42428-7"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/199108\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:02:41Z","timestamp":1781460161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/199108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6,15]]},"published-print":{"date-parts":[[2026,6,15]]}},"alternative-id":["10.1172\/JCI199108"],"URL":"https:\/\/doi.org\/10.1172\/jci199108","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"article-number":"e199108"}}