{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:12:32Z","timestamp":1779214352242,"version":"3.51.4"},"reference-count":16,"publisher":"American Society for Clinical Investigation","issue":"21","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:p>\n                    Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an adult-onset inflammatory disorder caused by somatic\n                    <jats:italic>UBA1<\/jats:italic>\n                    mutations in hematopoietic stem cells.\n                    <jats:italic>UBA1<\/jats:italic>\n                    encodes a key enzyme that catalyzes protein ubiquitination. Clinically, VEXAS is characterized by systemic inflammation and hematologic abnormalities. Patient studies have hinted that the transition of\n                    <jats:italic>UBA1<\/jats:italic>\n                    -mutated stem cells into proinflammatory myeloid precursors may propagate the manifestations of VEXAS syndrome. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Dong and colleagues developed nine unique conditional knockout mouse strains and found that only neutrophil-specific\n                    <jats:italic>Uba1<\/jats:italic>\n                    deletion reproduced VEXAS syndrome\u2013like findings. The observed phenotype was at least in part due to inflammatory reprogramming and longer survival of the mutant neutrophils. In addition to deepening our mechanistic understanding of VEXAS syndrome pathogenesis, this work should provide a platform to pursue more targeted approaches to treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci199299","type":"journal-article","created":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:01:03Z","timestamp":1762110063000},"source":"Crossref","is-referenced-by-count":0,"title":["Neutrophils take center stage in VEXAS syndrome pathogenesis"],"prefix":"10.1172","volume":"135","author":[{"given":"Ajay","family":"Tambralli","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, and"},{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-9771","authenticated-orcid":true,"given":"Jason S.","family":"Knight","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026834"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24836"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/art.42802"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead240"},{"key":"B5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224819"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224460"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27169"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101160"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016985"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44811-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00113"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16635"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107245"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae550"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI193011"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/199299\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:58:07Z","timestamp":1779213487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/199299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":16,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,8,28]]},"published-print":{"date-parts":[[2025,11,3]]}},"alternative-id":["10.1172\/JCI199299"],"URL":"https:\/\/doi.org\/10.1172\/jci199299","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"article-number":"e199299"}}