{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:06:05Z","timestamp":1779213965624,"version":"3.51.4"},"reference-count":24,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    Estrogen receptor \u03b1 (ESR1) is a pivotal regulator of endometrial homeostasis and reproductive function, yet the coregulators that fine tune its transcriptional activity remain incompletely defined. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Hewitt et al. identified Zinc finger MIZ-type containing 1 (ZMIZ1) as an ESR1 coregulator that is essential for stromal proliferation, decidualization, and overall endometrial integrity. ZMIZ1 deficiency was associated with endometriosis and endometrial cancer, and conditional ablation of\n                    <jats:italic>Zmiz1<\/jats:italic>\n                    using the\n                    <jats:italic>\n                      Pgr\n                      <jats:sup>Cre<\/jats:sup>\n                    <\/jats:italic>\n                    mouse led to infertility and accelerated fibrosis due to impaired estrogen responsiveness. These findings position ZMIZ1 as a key modulator of estrogen signaling with translational potential as both a biomarker and a therapeutic target in uterine disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci199976","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T19:00:54Z","timestamp":1764529254000},"source":"Crossref","is-referenced-by-count":1,"title":["ZMIZ1 and estrogen receptor \u03b1 form an essential partnership in endometrial biology"],"prefix":"10.1172","volume":"135","author":[{"given":"Md Saidur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology & Women\u2019s Health, University of Missouri School of Medicine, Columbia, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong A","family":"So","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology & Women\u2019s Health, University of Missouri School of Medicine, Columbia, Missouri, USA."},{"name":"Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Wook","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology & Women\u2019s Health, University of Missouri School of Medicine, Columbia, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI193212"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-022-02216-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163796"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/srep13735"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0366"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.01076"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231349"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-835850"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3516"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt024"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.037"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0431"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad020"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14900"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.074"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2383"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.11.014"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.77"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59882-y"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1530\/JME-23-0133"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1389"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1045"},{"key":"B24","article-title":"The interplay between endometriosis and obesity","author":"Rahman","journal-title":"Trends Endocrinol Metab"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/199976\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:08:49Z","timestamp":1779210529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/199976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":24,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,10,9]]},"published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1172\/JCI199976"],"URL":"https:\/\/doi.org\/10.1172\/jci199976","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"article-number":"e199976"}}