{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:17:41Z","timestamp":1790572661122,"version":"4.1.0"},"reference-count":60,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273517,82473519,82304005"],"award-info":[{"award-number":["82273517,82473519,82304005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Vitiligo is an autoimmune skin disease characterized by depigmentation, mainly due to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013mediated destruction of melanocytes. Hyperglycemia exacerbates autoimmune responses and is associated with vitiligo; however, the underlying immunometabolic mechanisms are poorly understood. Here, we demonstrated the correlation between hyperglycemia and vitiligo in a case-control study and demonstrated that hyperglycemia aggravated vitiligo based on a mouse model. Targeted metabolomics identified succinate as the potential metabolite mediating hyperglycemia-aggravated vitiligo. Mechanistically, succinate promotes the activation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells through succinate receptor 1 (SUCNR1) and promotes keratinocytes to secrete CXCL9 and CXCL10 by enhancing the stability and nuclear translocation of hypoxia-inducible factor-1\u03b1, facilitating the skin-homing of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Thus, hyperglycemia aggravates vitiligo through succinate\/SUCNR1 axis\u2013regulated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell hyperactivation. Our study provides insights into the long-observed yet previously unclear mechanism by which hyperglycemia accelerates vitiligo progression and highlights SUCNR1 as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1172\/jci200316","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:01:06Z","timestamp":1781460066000},"source":"Crossref","is-referenced-by-count":3,"title":["Hyperglycemia aggravates vitiligo through succinate\/SUCNR1-mediated T cell activation"],"prefix":"10.1172","volume":"136","author":[{"given":"Pan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, 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