{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:05:42Z","timestamp":1779213942246,"version":"3.51.4"},"reference-count":14,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    Pancreatic cancer cells \u201clive on the edge,\u201d starved of nutrients, compressed by abundant stiff stroma, and deprived of oxygen. In this issue, Xu et al. leveraged human pancreas organoid\u2013based CRISPR screens to identify new driver genes in pancreatic ductal adenocarcinoma (PDAC) development. Neurofibromatosis type 2 (\n                    <jats:italic>NF2<\/jats:italic>\n                    ) emerged as the top tumor suppressor, whose loss enhances PDAC malignancy. Inactivation of\n                    <jats:italic>NF2<\/jats:italic>\n                    , which encodes the protein Merlin, promoted growth factor independence and enhanced macropinocytosis upon nutrient deprivation. Thus,\n                    <jats:italic>NF2<\/jats:italic>\n                    status dictates the adaptability of pancreatic tumors under nutrient limitation, with\n                    <jats:italic>NF2<\/jats:italic>\n                    inactivation endowing PDACs with the ability to survive the constraints of the harsh tumor microenvironment.\n                  <\/jats:p>","DOI":"10.1172\/jci200909","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T19:01:04Z","timestamp":1767294064000},"source":"Crossref","is-referenced-by-count":0,"title":["Merlin\u2019s disappearing act: NF2 loss conjures pancreatic cancer survival in the hostile tumor microenvironment"],"prefix":"10.1172","volume":"136","author":[{"given":"Sofia","family":"Ferreira","sequence":"first","affiliation":[{"name":"Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Attardi","sequence":"additional","affiliation":[{"name":"Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.4708"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/path.5260"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164368"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature14169"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.054"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.07.014"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0633"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI194395"},{"key":"B10","article-title":"Merlin-YAP signaling: emerging mechanisms, functions, and therapeutic approaches","author":"Guo","journal-title":"Trends Cell Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.2.010506.091940"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.12.009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1952"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature12138"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/200909\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:06:18Z","timestamp":1779210378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/200909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,2]]},"published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["10.1172\/JCI200909"],"URL":"https:\/\/doi.org\/10.1172\/jci200909","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"article-number":"e200909"}}