{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:05:30Z","timestamp":1779213930511,"version":"3.51.4"},"reference-count":22,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    Transplantation of allogeneic islets of Langerhans, which include the insulin-producing \u03b2 cells of the endocrine pancreas, holds curative potential for type 1 diabetes (T1D). However, protecting the allograft from the host immune system has long been a challenge impeding wider use of this therapy. Inducing mixed hematopoietic chimerism via allogeneic hematopoietic stem cell transplantation (HSCT) can achieve long-lasting donor-specific immune tolerance, but the toxicities of conventional HSCT conditioning agents limit the use of this approach. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Bhagchandani et al. have used the JAK1\/2 inhibitor baricitinib to optimize a nonmyeloablative antibody-based HSCT conditioning regimen, achieving multilineage hematopoietic engraftment, which enabled curative islet allotransplantation in a mouse model of T1D.\n                  <\/jats:p>","DOI":"10.1172\/jci201105","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T19:01:04Z","timestamp":1767294064000},"source":"Crossref","is-referenced-by-count":0,"title":["Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal"],"prefix":"10.1172","volume":"136","author":[{"given":"Stephen P.","family":"Persaud","sequence":"first","affiliation":[{"name":"Division of Laboratory and Genomic Medicine, Department of Pathology & Immunology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"DiPersio","sequence":"additional","affiliation":[{"name":"Section of Cellular Therapy, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"issue":"1 pt 3","key":"B1","first-page":"2744","article-title":"Human islet transplantation in patients with type I diabetes","volume":"21","author":"Scharp","year":"1989","journal-title":"Transplant Proc"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829f7515"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3584"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145501"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08201-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41153-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.032"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bict.2025.100012"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.08.015"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012457"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-858159"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03817-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021120"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011075"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1264496"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI190034"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111615"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2003.12.003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2249237"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01784-x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2503822"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2506549"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/201105\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:05:28Z","timestamp":1779210328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/201105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,2]]},"published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["10.1172\/JCI201105"],"URL":"https:\/\/doi.org\/10.1172\/jci201105","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"article-number":"e201105"}}