{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:59:32Z","timestamp":1787018372243,"version":"build-2736575974"},"reference-count":17,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    Chimeric antigen receptor T cell (CAR-T) therapy has transformed the treatment of hematologic malignancies, yet, severe inflammatory toxicities continue to limit its broader use. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Goala et al. uncovered a mechanistic link between IFN-\u03b3\u2013driven inflammation and disrupted neutrophil homeostasis, revealing that cytokine release syndrome (CRS) and immune cell\u2013associated hematologic toxicity (ICAHT) stem from a shared biological pathway. Using IL-2Ra\u2013deficient mice and patient samples, they showed that IFN-\u03b3 suppressed IL-17A and granulocyte colony-stimulating factor (G-CSF), disrupting granulopoiesis and neutrophil survival. Strikingly, IFN-\u03b3 blockade eased both CRS and neutropenia without diminishing CAR-T efficacy, suggesting a path toward safer, better-tolerated cell therapies.\n                  <\/jats:p>","DOI":"10.1172\/jci201161","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T19:01:04Z","timestamp":1767294064000},"source":"Crossref","is-referenced-by-count":1,"title":["Fanning the flames: IFN-\u03b3 fuels CAR-T inflammation and cytopenia"],"prefix":"10.1172","volume":"136","author":[{"given":"Stefanie R.","family":"Bailey","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-0393","authenticated-orcid":true,"given":"Marcela V.","family":"Maus","sequence":"additional","affiliation":[{"name":"Cellular Immunotherapy Program, Mass General Cancer Center, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Masschusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017414"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004142"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017415"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI194631"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041982"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90180-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01959-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01960-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.9.4783"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.11.6383"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0203"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38723-y"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0181"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp8166"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101158"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04585-5"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/201161\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:05:35Z","timestamp":1779210335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/201161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,2]]},"published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["10.1172\/JCI201161"],"URL":"https:\/\/doi.org\/10.1172\/jci201161","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"article-number":"e201161"}}