{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:47:55Z","timestamp":1780580875877,"version":"3.54.1"},"reference-count":23,"publisher":"American Society for Clinical Investigation","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,16]]},"abstract":"<jats:p>\n                    Chronic stress triggers a range of physiological responses that could dysregulate the immune system and metabolic processes, thereby increasing susceptibility to various diseases. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Wu et al. identified a metabolic bridge between chronic stress and liver cancer progression. Chronic stress\u2013induced glucocorticoids promoted aminopeptidase N (ANPEP) expression and subsequent reprogramming of amino acid metabolism, leading to increased liver cancer growth and metastasis. ANPEP facilitated stabilization of the cystine-glutamate transporter system X\n                    <jats:sub>c<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    and increased l-cystine influx, thereby enhancing cellular antioxidant capacity to prevent ferroptosis. Silencing ANPEP in combination with sorafenib treatment showed a synergistic inhibitory effect on liver cancer progression. These findings uncover ANPEP as a valuable target for therapeutic interventions to treat patients with liver cancer experiencing chronic stress.\n                  <\/jats:p>","DOI":"10.1172\/jci202410","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T19:00:58Z","timestamp":1771182058000},"source":"Crossref","is-referenced-by-count":2,"title":["Aminopeptidase N: the glucocorticoid gateway linking chronic stress to ferroptosis resistance in liver cancer"],"prefix":"10.1172","volume":"136","author":[{"given":"Maowu","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-0320","authenticated-orcid":true,"given":"Weibo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology and"},{"name":"Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-23-25"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-025-07288-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00395-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0228-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.01.013"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06568-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nm1447"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13617"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2415042122"},{"issue":"4","key":"B11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI195685","article-title":"Chronic stress\u2013induced ANPEP drives liver cancer progression by increasing glutathione synthesis and inhibiting ferroptosis","volume":"136","author":"Wu","year":"2026","journal-title":"J Clin Invest"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188641"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.026328"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0922"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144908"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00494.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10120481"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201804161"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01480.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101942"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030724"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06435-w"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200005000-00002"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/202410\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:44:08Z","timestamp":1779209048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/202410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2,16]]},"published-print":{"date-parts":[[2026,2,16]]}},"alternative-id":["10.1172\/JCI202410"],"URL":"https:\/\/doi.org\/10.1172\/jci202410","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"article-number":"e202410"}}