{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:28:19Z","timestamp":1782984499906,"version":"3.54.5"},"reference-count":12,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:p>\n                    Neurodegeneration, along with amyloid and tau, define the AT(N) framework of Alzheimer\u2019s disease that has shaped the development of diagnostics and therapeutics. Yet, biomarker development for neurodegeneration has lagged behind that for amyloid and tau, with limited definition of its heterogeneous microstructural aspects that may each serve as critical measures. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Gong et al. leveraged diffusion MRI to derive a unique measure of axonal injury or axonal density index (ADI). Through cross-sectional and longitudinal analyses, they demonstrated that the ADI has superior performance in detecting, tracking, and predicting clinical impairment compared with prior diffusion MRI methods to evaluate axonal health and standard biomarkers of amyloid and tau. As such, the ADI measure may serve as an important expansion of the neurodegeneration biomarker repertoire.\n                  <\/jats:p>","DOI":"10.1172\/jci202411","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:01:17Z","timestamp":1769972477000},"source":"Crossref","is-referenced-by-count":1,"title":["Neurodegeneration biomarkers in Alzheimer\u2019s disease: axonal density index expands the \u201cN\u201d in the AT(N) framework"],"prefix":"10.1172","volume":"136","author":[{"given":"Ryn","family":"Flaherty","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, CRMBM, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun V.","family":"Masurkar","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology, Department of Neurology, and Department of Neuroscience, NYU Grossman School of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02503-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0515-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082312"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2024.103593"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01698-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1205426"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3998"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.005"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI196638"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/202411\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:45:22Z","timestamp":1779209122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/202411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,2]]},"published-print":{"date-parts":[[2026,2,2]]}},"alternative-id":["10.1172\/JCI202411"],"URL":"https:\/\/doi.org\/10.1172\/jci202411","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"article-number":"e202411"}}