{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:59:40Z","timestamp":1789707580712,"version":"4.0.1"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2023YFA1800804"],"award-info":[{"award-number":["2023YFA1800804"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0530604"],"award-info":[{"award-number":["2024ZD0530604"]}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB0830402"],"award-info":[{"award-number":["XDB0830402"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U22A20272,82270601,82300516"],"award-info":[{"award-number":["U22A20272,82270601,82300516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:p>\n                    Hepatic stellate cell (HSC) activation can lead to liver fibrosis, for which there are no effective treatments. Aberrant cytoskeletal reorganization is a central driver of HSC activation. Non-muscle myosin II (NM II) is known to regulate cytoskeleton remodeling via its actin cross-linking and contractile properties. However, the molecular players controlling actomyosin assembly and contractility in HSCs during liver fibrosis remain poorly defined. Here, we identified integrin \u03b2-like 1 (ITGBL1) as a gatekeeper of HSC quiescence by negatively regulating actomyosin contractility-driven mechanotransduction in HSCs. ITGBL1 expression was markedly elevated in activated HSCs found in patient and mouse fibrotic livers. Unexpectedly, HSC-specific\n                    <jats:italic>Itgbl1<\/jats:italic>\n                    deficiency worsened liver fibrosis, whereas ITGBL1 overexpression in HSCs limited it, suggesting a protective role for ITGBL1 against a pathogenic HSC activation. Multiomics and functional analyses revealed that ITGBL1 impaired F-actin filament organization in HSCs by disrupting actomyosin assembly dependent on myosin heavy chain 9 (MYH9, also named NM II heavy chain A). In line, HSC-specific\n                    <jats:italic>Myh9<\/jats:italic>\n                    deficiency or silencing of\n                    <jats:italic>Myh9<\/jats:italic>\n                    in HSCs alleviated liver fibrosis. Taken together, our findings unveil that ITGBL1-MYH9 interaction acts as a critical mechanoregulatory brake that maintains cytoskeletal equilibrium and mechanical homeostasis in HSCs, providing a promising therapeutic strategy to combat liver fibrosis.\n                  <\/jats:p>","DOI":"10.1172\/jci203412","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:00:33Z","timestamp":1784217633000},"source":"Crossref","is-referenced-by-count":1,"title":["ITGBL1-MYH9 interaction in hepatic stellate cells acts as a mechanoregulator controlling liver fibrosis in mice"],"prefix":"10.1172","volume":"136","author":[{"given":"Yixin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China."},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese 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