{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:02:05Z","timestamp":1781809325150,"version":"3.54.5"},"reference-count":25,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>TMPRSS2:ERG<\/jats:italic>\n                    gene fusion is a truncal oncogenic event in a large subset of prostate cancers, yet its clinical relevance has remained unclear. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , K\u00f6cher et al. have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly(ADP-ribose) polymerase 1\u2013dependent (PARP1-dependent) alternative end-joining pathway without disrupting canonical repair. This repair bias created a conditional dependency on PARP1 that was exposed by radiotherapy, rendering ERG-positive tumors selectively sensitive to PARP inhibition\u2013mediated radiosensitization. The tumor-selective cytotoxic effect of combined PARP1 inhibition and irradiation was corroborated in human-derived prostate cancer organoids. These findings establish ERG as a predictive biomarker for precision radiotherapy and highlight a tumor-selective strategy to enhance radiotherapeutic efficacy in prostate cancer.\n                  <\/jats:p>","DOI":"10.1172\/jci203657","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:00:52Z","timestamp":1773597652000},"source":"Crossref","is-referenced-by-count":2,"title":["TMPRSS2:ERG\u2013directed radiosensitization: exploiting DNA repair rewiring in gene fusion\u2013positive prostate cancer"],"prefix":"10.1172","volume":"136","author":[{"given":"Xiaoju","family":"Wang","sequence":"first","affiliation":[{"name":"Michigan Center for Translational Pathology,"},{"name":"Department of Pathology,"},{"name":"Rogel Cancer Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul M.","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology,"},{"name":"Department of Pathology,"},{"name":"Rogel Cancer Center,"},{"name":"Howard Hughes Medical Institute, and"},{"name":"Department of Urology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"issue":"1","key":"B1","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.68"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61095-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i5.632"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2402"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117679"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1593\/neo.07822"},{"issue":"6","key":"B8","doi-asserted-by":"crossref","DOI":"10.1172\/JCI194949","article-title":"Overexpression of the ERG oncogene in prostate cancer identifies candidates for PARP inhibitor\u2013based radiosensitization","volume":"136","author":"K\u00f6cher","year":"2026","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ng1935"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1961"},{"key":"B12","doi-asserted-by":"crossref","unstructured":"Sekar A, et al. TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications [preprint]. https:\/\/doi.org\/10.1101\/2025.01.17.633582 Posted on bioRxiv January 20, 2025","DOI":"10.1101\/2025.01.17.633582"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215612"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7344"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506859"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq387"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.06.008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.07.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.03.018"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ng.613"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911440"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.10.040"},{"issue":"1","key":"B24","first-page":"93","article-title":"Recent advances in the microbiology of respiratory tract infection in cystic fibrosis","volume":"89","author":"Chalmers","year":"2009","journal-title":"Br Med Bull"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30102-4"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/203657\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:42:48Z","timestamp":1779208968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/203657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3,16]]},"published-print":{"date-parts":[[2026,3,16]]}},"alternative-id":["10.1172\/JCI203657"],"URL":"https:\/\/doi.org\/10.1172\/jci203657","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"article-number":"e203657"}}