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Extrafollicular (EF) B cell responses contribute to SLE pathogenesis, with age-associated B cells (ABCs) giving rise to autoantibody-secreting plasmablasts (PBs). However, the migratory cues governing this EF trajectory remain unclear. Here, we identify a distinct ABC state with PB precursor characteristics (pre-PB ABCs) and reveal a migration-dependent program underlying their generation. Single-cell analysis of patients with SLE and model mice showed that pre-PB ABCs were enriched in autoreactive clones and poised for PB differentiation. Their frequency correlated with autoantibody titers and disease activity, underscoring their pathogenic relevance. We further demonstrated that the oxysterol receptor EBI2 directed ABCs to EF niches within splenic bridging channels, promoting pre-PB ABC formation and autoreactive PB output. This process depended on the COMMD3\/8 complex, a positive regulator of chemoattractant receptor signaling. Beyond EBI2-mediated ABC migration to EF niches, the COMMD3\/8 complex was also required for trafficking of autoantibody-secreting cells to the bone marrow and infiltration of ABCs into the kidney. Accordingly, COMMD3\/8 complex inhibition ameliorated disease in murine SLE models. These findings define a migration-dependent mechanism driving the EF differentiation of ABCs into autoreactive PBs and shaping the tissue distribution of pathogenic B cells, highlighting this program as a potential therapeutic target in SLE.<\/jats:p>\n                  <jats:p\/>\n                  <jats:p>Migration-dependent extrafollicular programming generates autoreactive pre-plasmablast ABCs in lupus; COMMD3\/8 complex inhibition disrupts this axis and ameliorates disease.<\/jats:p>","DOI":"10.1172\/jci204095","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:00:33Z","timestamp":1784044833000},"source":"Crossref","is-referenced-by-count":3,"title":["Migration-dependent extrafollicular programming of preplasmablast age-associated B cells drives lupus pathogenesis"],"prefix":"10.1172","volume":"136","author":[{"given":"Taiichiro","family":"Shirai","sequence":"first","affiliation":[{"name":"Laboratory of Immune Response Dynamics, WPI 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