{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:28:39Z","timestamp":1790980119663,"version":"4.1.0"},"reference-count":70,"publisher":"American Society for Clinical Investigation","issue":"14","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health and the National Cancer Institute","award":["R01-CA233662"],"award-info":[{"award-number":["R01-CA233662"]}]},{"DOI":"10.13039\/100009164","name":"H. 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In patients with solid tumors, CH is associated with higher mortality and may evolve to therapy-related myeloid neoplasms; however, the mechanisms by which cancer treatments promote CH dynamics remain largely unknown. Here, we analyzed 392 serial samples from a prospective cohort of patients with breast cancer and show that cytotoxic treatments led to strong therapeutic bottlenecks, resulting in significant reductions in hematopoietic allelic populations and differential clonal selection. Positively selected CH that expanded through dose-dependent therapeutic bottlenecks harbored mutations in\n                    <jats:italic>TP53<\/jats:italic>\n                    ,\n                    <jats:italic>PPM1D<\/jats:italic>\n                    ,\n                    <jats:italic>SRCAP<\/jats:italic>\n                    ,\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    , and\n                    <jats:italic>YLPM1<\/jats:italic>\n                    . Patients with positively selected CH during treatment had the shortest progression-free and overall survival compared with patients with unchanging or negatively selected CH across all therapies. These findings, validated in independent breast cancer and pan-cancer cohorts, provide strong evidence for the clinical relevance of monitoring CH during cancer treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci204429","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:01:12Z","timestamp":1781020872000},"source":"Crossref","is-referenced-by-count":3,"title":["Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes"],"prefix":"10.1172","volume":"136","author":[{"given":"Mona","family":"Arabzadeh","sequence":"first","affiliation":[{"name":"Center for Systems and Computational Biology, and"},{"name":"Center for Biomedical Informatics, Bioinformatics Department, Rutgers Cancer Institute, Rutgers University, New Brunswick, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Han","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cancer 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