{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:10:21Z","timestamp":1779210621123,"version":"3.51.4"},"reference-count":22,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    Crohn\u2019s disease can occur anywhere along the small and\/or large intestines, but most commonly occurs in the terminal ileum or ascending colon. Factors governing this region-specific inflammation are poorly understood. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Spencer et al. used a TNF-driven mouse model of small intestinal Crohn\u2019s disease to identify a specific bacterial pathobiont,\n                    <jats:italic>Chlamydia muridarum<\/jats:italic>\n                    , as a necessary and sufficient driver of region-restricted inflammation.\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>muridarum<\/jats:italic>\n                    triggered increased goblet cell expression of indoleamine 2,3-dioxygenase 1 (IDO1) in the mouse proximal colon, analogous to the human ascending colon. IDO1 metabolism of tryptophan stimulated increased levels of kyneurine, and suppression of this IDO1\/kyneurine axis alleviated\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>muridarum\u2013<\/jats:italic>\n                    provoked inflammation in the proximal colon but not the terminal ileum. Analysis of scRNA-seq datasets from patients with Crohn\u2019s disease with ascending colon involvement also supported increased IDO1 expression in a subpopulation of crypt surface epithelial cells. The study highlights a process by which bacterial pathobionts promote region-specific intestinal inflammation.\n                  <\/jats:p>","DOI":"10.1172\/jci204928","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:00:57Z","timestamp":1774980057000},"source":"Crossref","is-referenced-by-count":0,"title":["Goblet of fire: how Chlamydia ignites region-specific colitis by hijacking goblet cells"],"prefix":"10.1172","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-0802","authenticated-orcid":true,"given":"Declan F.","family":"McCole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","unstructured":"Yu Z, et al. Cytokine networks in Paneth cell regulation [pubished online January 29, 2026]. Mucosal Immunol. https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.010","DOI":"10.1016\/j.mucimm.2026.01.010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.101443"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191997"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006451107"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3738"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-335331"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.10.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.30"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203937200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.07.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949756"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16086"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05659-11"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI201729"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80038-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1791"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51580-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00046.2013"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay7367"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05989-7"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/204928\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:42:04Z","timestamp":1779208924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/204928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,2,17]]},"published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1172\/JCI204928"],"URL":"https:\/\/doi.org\/10.1172\/jci204928","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"article-number":"e204928"}}