{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:28Z","timestamp":1792787608494,"version":"4.5.0"},"reference-count":4,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Society of Nephrology","award":["Kidney Cure Ben J. Lipps Research Fellowship Program"],"award-info":[{"award-number":["Kidney Cure Ben J. Lipps Research Fellowship Program"]}],"id":[{"id":"https:\/\/ror.org\/014pcm848","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["R21DK106584"],"award-info":[{"award-number":["R21DK106584"]}]},{"name":"Subaward Critical Path Institute FDA","award":["75F40124C00106"],"award-info":[{"award-number":["75F40124C00106"]}],"id":[{"id":"https:\/\/ror.org\/02mgtg880","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["R01 DK112921,UH2 TR002065"],"award-info":[{"award-number":["R01 DK112921,UH2 TR002065"]}]},{"name":"Juvenile Diabetes Research Foundation","award":["17-2013-410,2-SRA-2018-496-A-B"],"award-info":[{"award-number":["17-2013-410,2-SRA-2018-496-A-B"]}]},{"name":"Finnish Diabetes Research Foundation","award":["grants from the Finnish Diabetes Research Foundation"],"award-info":[{"award-number":["grants from the Finnish Diabetes Research Foundation"]}],"id":[{"id":"https:\/\/ror.org\/004j3q729","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Academy of Finland","award":["117044,333974"],"award-info":[{"award-number":["117044,333974"]}],"id":[{"id":"https:\/\/ror.org\/05k73zm37","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Center for Selective C-H Functionalization, National Science Foundation","award":["CBET-2316285,CBET-2331330"],"award-info":[{"award-number":["CBET-2316285,CBET-2331330"]}],"id":[{"id":"https:\/\/ror.org\/02h8v7m77","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Congressionally Directed Medical Research Programs","award":["HT94252310996"],"award-info":[{"award-number":["HT94252310996"]}],"id":[{"id":"https:\/\/ror.org\/03g2zjp07","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["2DK105056-6,R56DK138158A1,R21DK131557A1,R03DK106451,K08DK089015"],"award-info":[{"award-number":["2DK105056-6,R56DK138158A1,R21DK131557A1,R03DK106451,K08DK089015"]}]},{"name":"VA Merit","award":["I01BX006401A1"],"award-info":[{"award-number":["I01BX006401A1"]}]},{"name":"the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program under Award","award":["W81XWH-19-1-0320"],"award-info":[{"award-number":["W81XWH-19-1-0320"]}],"id":[{"id":"https:\/\/ror.org\/03b7pda13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"George M. O\u2019Brien Kidney Research Core Centers","award":["NIH P30 DK114857,NIH P30 DK079337"],"award-info":[{"award-number":["NIH P30 DK114857,NIH P30 DK079337"]}]},{"name":"WashU Center of Regenerative Medicine","award":["Seed Grant from WashU Center of Regenerative Medicine"],"award-info":[{"award-number":["Seed Grant from WashU Center of Regenerative Medicine"]}]},{"name":"WashU Center for Drug Discovery","award":["Mallinckrodt Challenge Grant,Investigator Matching Micro Grant"],"award-info":[{"award-number":["Mallinckrodt Challenge Grant,Investigator Matching Micro Grant"]}]},{"name":"Children\u2019s Discovery Institute of WashU and St. Louis Children\u2019s Hospital","award":["Faculty Scholar Award"],"award-info":[{"award-number":["Faculty Scholar Award"]}],"id":[{"id":"https:\/\/ror.org\/00qw1qw03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Washington University Institute of Clinical and Translational Sciences","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}]},{"name":"Diabetes Research Center","award":["NIH P30 DK020579"],"award-info":[{"award-number":["NIH P30 DK020579"]}],"id":[{"id":"https:\/\/ror.org\/05g02g987","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Center for Research Resources","award":["NCI Cancer Center Support Grant #P30 CA91842"],"award-info":[{"award-number":["NCI Cancer Center Support Grant #P30 CA91842"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"DOI":"10.1172\/jci205631","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:00:37Z","timestamp":1787673637000},"source":"Crossref","is-referenced-by-count":0,"title":["MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease"],"prefix":"10.1172","volume":"136","author":[{"given":"Chenjian","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-0141","authenticated-orcid":true,"given":"Eric","family":"Tycksen","sequence":"additional","affiliation":[{"name":"Genome Technology Access Center, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Kondepati","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-0949","authenticated-orcid":true,"given":"Kendrah O.","family":"Kidd","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai General Hospital, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-6293","authenticated-orcid":true,"given":"Fumihiko","family":"Urano","sequence":"additional","affiliation":[{"name":"Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lindahl","sequence":"additional","affiliation":[{"name":"University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Bleyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Singamaneni","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Maggie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine,"},{"name":"St. Louis Veteran Affairs Medical Center, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42154-0"},{"key":"B2","doi-asserted-by":"crossref","unstructured":"Lake BB, et al. Cellular and spatial drivers of unresolved injury and functional decline in the human kidney [preprint]. https:\/\/doi.org\/10.1101\/2025.09.26.678707 Posted on bioRxiv November 24, 2025","DOI":"10.1101\/2025.09.26.678707"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1813580116"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-0547-4"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/205631\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:56:30Z","timestamp":1792004190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/205631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":4,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2026,10,15]]},"published-print":{"date-parts":[[2026,10,15]]}},"alternative-id":["10.1172\/JCI205631"],"URL":"https:\/\/doi.org\/10.1172\/jci205631","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"article-number":"e205631"}}