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In this issue, Gherardini and colleagues described a targeted strategy to prevent CIA using ALRN-6924, a stapled peptide that transiently activates p53 and induces cell cycle arrest in proliferating TP53 wild-type tissues, such as the hair follicle. In ex vivo human scalp hair follicle culture, ALRN-6924 protected matrix keratinocytes and bulge stem cells from paclitaxel- and cyclophosphamide-induced injury, reducing apoptosis, DNA damage, and other pathologic features. These findings nominate precision chemoprotection as a promising supportive care approach for mitigating CIA.<\/jats:p>","DOI":"10.1172\/jci205966","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:00:58Z","timestamp":1777572058000},"source":"Crossref","is-referenced-by-count":0,"title":["Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the hair follicle"],"prefix":"10.1172","volume":"136","author":[{"given":"Edward B.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."},{"name":"Hair-Alopecia Innovation and Research Program, Northwestern Medicine, Chicago, Illinois, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Klay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."},{"name":"Hair-Alopecia Innovation and Research Program, Northwestern Medicine, Chicago, Illinois, USA."},{"name":"Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."},{"name":"Hair-Alopecia Innovation and Research Program, Northwestern Medicine, Chicago, Illinois, USA."},{"name":"Department of Pathology,"},{"name":"Driskill Graduate Program in Life Sciences, and"},{"name":"Robert H. 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