{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:09:42Z","timestamp":1780337382435,"version":"3.54.1"},"reference-count":25,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    Liver fibrosis is a common pathological outcome of chronic liver disease and is driven by inflammatory responses. However, the early signals that initiate the inflammatory cascade remain poorly understood. Emerging evidence suggests that liver sinusoidal endothelial cells (LSECs) are not merely passive bystanders, but active regulators during liver fibrosis. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Gan et al. demonstrated in multiple preclinical models that BRD4\/PML-mediated super-enhancer activation in LSECs drives proinflammatory angiocrine signaling, thereby initiating liver fibrosis. Thus, targeting this endothelial axis may offer a promising therapeutic strategy for the treatment of liver fibrosis.\n                  <\/jats:p>","DOI":"10.1172\/jci206430","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:44:46Z","timestamp":1780335886000},"source":"Crossref","is-referenced-by-count":0,"title":["Sinusoidal endothelial cells control liver inflammation and fibrosis"],"prefix":"10.1172","volume":"136","author":[{"given":"Yingfen","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China."},{"name":"University of Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China."},{"name":"University of Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00832-w"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00807-x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/egastro-2023-100040"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.10.017"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.05.014"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.033"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab148"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.02.032"},{"key":"B13","article-title":"Endothelial RAP1A attenuates sinusoidal capillarisation and liver fibrosis by inhibiting RAF1-mediated Notch activation","author":"Chen","journal-title":"Gut"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01313-7"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.03.029"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31617"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143690"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI196730"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa828"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2025.09.006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2413258"},{"key":"B23","article-title":"Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis","author":"Hu","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59885-x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55325-4"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/206430\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:45:18Z","timestamp":1780335918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/206430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,4,9]]},"published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1172\/JCI206430"],"URL":"https:\/\/doi.org\/10.1172\/jci206430","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"article-number":"e206430"}}