{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:11:03Z","timestamp":1782846663999,"version":"3.54.5"},"reference-count":17,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    Immune checkpoint inhibitor\u2013induced inflammatory arthritis (ICI-IA) is an immune-related adverse event (irAE) following treatment with PD-1, PD-L1, or CTLA-4 inhibitors in patients with cancer. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Ma and colleagues identified a subset of regulatory T cells (Tregs) that coexpress CD137 and IL-6 receptor (IL6R), termed atypical Tregs (AtpTregs), which are selectively enriched in patients with ICI-IA. Functionally, AtpTregs exhibited reduced suppressive capacity and a Th17-like proinflammatory phenotype. Notably, these cells were associated with more severe arthritis, yet improved cancer outcomes, suggesting a potential role in tumor control. The anti-IL6R therapy tocilizumab, administered as an off-label intervention for ICI-IA, reduced AtpTreg abundance and alleviated arthritis while maintaining antitumor immunity in a small cohort of patients with new-onset ICI-IA. Thus, anti-IL6R could be a targeted approach to manage ICI-IA and potentially other irAEs involving AtpTregs.\n                  <\/jats:p>","DOI":"10.1172\/jci206592","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:30:13Z","timestamp":1782844213000},"source":"Crossref","is-referenced-by-count":0,"title":["Checkpoint inhibitors create rogue regulatory T cells"],"prefix":"10.1172","volume":"136","author":[{"given":"Smriti","family":"Parashar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-3672","authenticated-orcid":true,"given":"Klaus","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0074-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200135"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.014"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031420"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1628790"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195354"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.016"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.020"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01589-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-025-00322-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03493-5"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309764"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308648"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29539-3"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/206592\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:30:19Z","timestamp":1782844219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/206592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":17,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,5,12]]},"published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1172\/JCI206592"],"URL":"https:\/\/doi.org\/10.1172\/jci206592","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"e206592"}}