{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:53:52Z","timestamp":1781463232576,"version":"3.54.1"},"reference-count":25,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Historically, research on chylomicron entry into intestinal lymphatic vessels (lacteals) has been polarized between paracellular and transcellular transport models. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Sun et al. identified GPR182 as a lipoprotein receptor in lymphatic endothelial cells (LECs), profoundly advancing our understanding of intestinal lipid absorption. They observed poor fat absorption in GPR182-deficient mice and demonstrated the role of GPR182 in transporting chylomicrons across the LECs into the lacteal lumen. This discovery establishes a molecular basis for transcellular transport of chylomicrons, challenging the traditional view that lacteal lipid entry is predominantly paracellular. By linking receptor-mediated uptake to impaired fat absorption and protection against fat-induced obesity and steatosis, this study expands the biological and translational implications of lacteal transport. Consequently, rather than favoring a single model, future research should investigate the integration of both paracellular and transcellular transport models in vivo.\n                  <\/jats:p>","DOI":"10.1172\/jci207115","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:01:06Z","timestamp":1781460066000},"source":"Crossref","is-referenced-by-count":0,"title":["GPR182 and the reframing of lacteal chylomicron uptake"],"prefix":"10.1172","volume":"136","author":[{"given":"Liqing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.5.3.373"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1960.198.6.1326"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.15.2.259"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(66)80102-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106700"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(70)90117-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05716.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap9331"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201846927"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/24.1.77"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1218-x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00004"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27658-x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021596118"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1242531"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1297596"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200857"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12533"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00130"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318003"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313237"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/BST20200991"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27352"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.010"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/207115\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:02:02Z","timestamp":1781460122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/207115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":25,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6,15]]},"published-print":{"date-parts":[[2026,6,15]]}},"alternative-id":["10.1172\/JCI207115"],"URL":"https:\/\/doi.org\/10.1172\/jci207115","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"article-number":"e207115"}}