{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:56:17Z","timestamp":1790700977289,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Clinical Investigation","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Diabetes and Digestive and Kidney Disease","award":["K08DK124568"],"award-info":[{"award-number":["K08DK124568"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Disease","award":["R01DK 35423"],"award-info":[{"award-number":["R01DK 35423"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Disease","award":["U01DK 122013"],"award-info":[{"award-number":["U01DK 122013"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Disease","award":["R01 DK134675"],"award-info":[{"award-number":["R01 DK134675"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Disease","award":["R01DK130291"],"award-info":[{"award-number":["R01DK130291"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Heart, Lung, and Blood Institute","award":["R01HL170048"],"award-info":[{"award-number":["R01HL170048"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association","award":["25SFRNPCKMS463897"],"award-info":[{"award-number":["25SFRNPCKMS463897"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Chronic kidney disease (CKD) disrupts mineral homeostasis, leading to impaired skeletal mineralization and cardiovascular pathology, yet the mechanism linking these processes remains undefined. Here we identify glycerol-3-phosphate acyltransferase 2 (GPAT2) as a regulator that couples free fatty acid (FFA) partitioning in osteoblasts to systemic phosphate balance. In mouse and human CKD, elevated osteoblast GPAT2 routes FFA away from mitochondrial oxidation, limiting phosphate incorporation into bone, and toward lysophosphatidic acid synthesis, increasing production of the phosphaturic hormone fibroblast growth factor 23 (FGF23). By contrast, osteoblast-specific\n                    <jats:italic>Gpat2<\/jats:italic>\n                    deletion restores osteoblast FFA oxidation and skeletal phosphate incorporation, lowers circulating phosphate and FGF23, and attenuates vascular calcification and cardiac hypertrophy in CKD. Further, a bone-targeted GPAT inhibitor recapitulates most of these beneficial effects. These findings establish a fundamental role for osteoblast lipid metabolism in mineral homeostasis and identify GPAT2 in bone as a promising therapeutic target for both skeletal and cardiovascular complications of CKD.\n                  <\/jats:p>","DOI":"10.1172\/jci207322","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:34Z","timestamp":1790697634000},"source":"Crossref","is-referenced-by-count":0,"title":["Targeting osteoblast fatty acid metabolism attenuates skeletal and cardiovascular complications in chronic kidney disease models"],"prefix":"10.1172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-8561","authenticated-orcid":true,"given":"Petra","family":"Simic","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-6011","authenticated-orcid":true,"given":"Wen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangcong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Roh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro B.","family":"Salusky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology, David GeffenSchool of Medicine at UCLA, Los Angeles, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Khatri","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-7583","authenticated-orcid":true,"given":"Eugene P.","family":"Rhee","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,9,29]]},"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/207322\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:35Z","timestamp":1790697635000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/207322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":0,"alternative-id":["10.1172\/JCI207322"],"URL":"https:\/\/doi.org\/10.1172\/jci207322","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}