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Impairment of the homologous recombination DNA repair pathway \u2014 arising through somatic and germline mutations in homologous recombination repair genes, epigenetic mechanisms, and transcriptomic changes \u2014 leads to genomic instability and a reliance on error-prone repair mechanisms. Poly (ADP-ribose) polymerase (PARP) inhibitors harness the synthetic lethality of HRD and PARP inhibition, with current approvals encompassing both early-stage and advanced breast cancer in patients with germline\n                    <jats:italic>BRCA1\/2<\/jats:italic>\n                    (g\n                    <jats:italic>BRCA1\/2<\/jats:italic>\n                    ) mutations. However, emerging evidence suggests efficacy of PARP inhibitors beyond g\n                    <jats:italic>BRCA1\/2<\/jats:italic>\n                    -mutated breast cancer to tumors with other homologous recombination repair defects that confer a \u201cBRCAness\u201d phenotype. 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