{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:11:13Z","timestamp":1782846673974,"version":"3.54.5"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    Metabolic dysfunction\u2013associated steatohepatitis (MASH) is increasingly linked to disruptions of the gut\/liver axis, yet the microbial mechanisms driving disease progression remain incompletely defined. Here, Qu et al. have identified ileal microbial ammonia production by\n                    <jats:italic>Clostridium perfringens<\/jats:italic>\n                    as a mechanistic driver of epithelial barrier dysfunction and hepatic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell remodeling in MASH. In nonhuman primate and mouse models of MASH, the authors demonstrated that the glycine-based tripeptide DT-109 restored gut barrier integrity and attenuated FosB-mediated CCL5 expression in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells via inhibition of bacterial nitrite reductase A\u2013mediated microbial ammonia production. These findings position microbial nitrogen metabolism as a tractable therapeutic target and highlight metabolite-focused microbiome interventions as a potential MASH intervention.\n                  <\/jats:p>","DOI":"10.1172\/jci207921","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:30:13Z","timestamp":1782844213000},"source":"Crossref","is-referenced-by-count":0,"title":["Ammonia in the crosshairs: microbial targets for metabolic dysfunction\u2013associated steatohepatitis prevention"],"prefix":"10.1172","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-4377","authenticated-orcid":true,"given":"Vanessa A.","family":"Leone","sequence":"first","affiliation":[{"name":"Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arion","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Structural Biochemistry, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2413258"},{"issue":"13","key":"B5","doi-asserted-by":"crossref","DOI":"10.1172\/JCI200522","article-title":"Metabolic dysfunction\u2013associated steatohepatitis exacerbated by Clostridium perfringens\u2013derived ammonia is attenuated by tripeptide DT-109","volume":"136","author":"Qu","year":"2026","journal-title":"J Clin Invest"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109704"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.011"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2026.502664"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s44355-024-00011-x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-6"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2020.12.008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1279051"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114325"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03233-8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1302006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111564"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01503-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.03.013"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz2841"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/207921\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:31:41Z","timestamp":1782844301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/207921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":20,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,5,12]]},"published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1172\/JCI207921"],"URL":"https:\/\/doi.org\/10.1172\/jci207921","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"e207921"}}