{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:39:28Z","timestamp":1792687168470,"version":"4.5.0"},"reference-count":0,"publisher":"American Society for Clinical Investigation","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NCI","award":["R01CA251067"],"award-info":[{"award-number":["R01CA251067"]}]},{"name":"NCI","award":["R03CA280382"],"award-info":[{"award-number":["R03CA280382"]}]},{"name":"lung SPORE","award":["P50CA070907"],"award-info":[{"award-number":["P50CA070907"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Golgin-45 (G45) is a coiled-coil protein that transits reversibly between the Golgi and nucleus. In the Golgi, G45 serves as a tether for effectors of a pro-tumorigenic secretory program, but its nuclear role remains unclear. Here, we report that, upon entering the nucleus, G45 functions as a basic leucine zipper transcription factor. From genomic mapping, RNA-sequencing, and functional validation studies, we identify G45-binding sites and show that nuclear G45 can function as a transcriptional activator or repressor, a versatility enabled by phase separation into nuclear bodies enriched in transcriptional co-regulators. In lung cancer models, Golgi-docking reinforces, whereas nuclear translocation opposes, pro-tumorigenic activity of G45. Nuclear G45 incorporates into dimeric transcription factors that silence pro-tumorigenic secreted cargos. Epigenetic events in lung cancer degrade nuclear G45 and sequester G45 in the Golgi, which unleashes malignant secretion. Thus, inter-organelle transitions govern a G45-dependent secretory axis that drives lung cancer progression.<\/jats:p>","DOI":"10.1172\/jci209670","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:32Z","timestamp":1792684832000},"source":"Crossref","is-referenced-by-count":0,"title":["Impairing Golgin-45 transcription factor activity unleashes malignant secretion in lung cancer"],"prefix":"10.1172","author":[{"given":"Chao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-1916","authenticated-orcid":true,"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shike","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-4555","authenticated-orcid":true,"given":"William K.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Texas Medical Branch, Galveston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-fu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Kurie","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,10,22]]},"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/209670\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:34Z","timestamp":1792684834000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/209670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":0,"alternative-id":["10.1172\/JCI209670"],"URL":"https:\/\/doi.org\/10.1172\/jci209670","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]}}}