{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:13:32Z","timestamp":1789409612340,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:p>\n                    Multiple myeloma is a systemic and spatially heterogeneous cancer of plasma cells. Available methods for diagnosing and monitoring disease do not fully capture its heterogeneity. For instance, bone marrow sampling is anatomically limited and [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT reflects glucose metabolism rather than a specific target. In this issue of\n                    <jats:italic>JCI<\/jats:italic>\n                    , Gu et al. reported a prospective phase I study of [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga-PFBC01, a nanobody tracer targeting B cell maturation antigen (BCMA). The study presents a coherent translational pathway for [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga-PFBC01 PET and demonstrates high sensitivity, associations with tissue and circulating disease measures, and clinical management impact. By shifting myeloma imaging from metabolic assessment toward target biology, [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga-PFBC01 PET may visualize whole-body disease distribution and actionable target expression, while blood-pool activity may reflect systemic antigen biology (Figure 1).\n                  <\/jats:p>","DOI":"10.1172\/jci210178","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:01:18Z","timestamp":1789408878000},"source":"Crossref","is-referenced-by-count":0,"title":["Imaging B cell maturation antigen in multiple myeloma"],"prefix":"10.1172","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-1736","authenticated-orcid":true,"given":"Yangmeihui","family":"Song","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."},{"name":"Hubei Key Laboratory of Molecular Imaging, Wuhan, Hubei, China."},{"name":"Hubei Provincial Clinical Medical Research Center for Medical Imaging, Wuhan, Hubei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."},{"name":"Hubei Key Laboratory of Molecular Imaging, Wuhan, Hubei, China."},{"name":"Hubei Provincial Clinical Medical Research Center for Medical Imaging, Wuhan, Hubei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Cai","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00296-y"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-03984-w"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30189-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-774422"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361386"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2025.12.004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI207391"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01758-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8333"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000050"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02491-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024965"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02518-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30788-0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265670"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01017-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019181949"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/210178\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:01:21Z","timestamp":1789408881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/210178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":19,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,6,30]]},"published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1172\/JCI210178"],"URL":"https:\/\/doi.org\/10.1172\/jci210178","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"article-number":"e210178"}}