{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:45:50Z","timestamp":1792007150481,"version":"4.4.0"},"reference-count":14,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>\n                    Efferocytosis, or the clearance of apoptotic cells by macrophages, has been implicated in tissue resolution that promotes disease regression in atherosclerosis and other diseases of chronic inflammation. The mechanisms by which efferocytosis leads to pro-resolving macrophage reprogramming have not been fully defined. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Avrampou and colleagues found that efferocytosis activates DNA-methyltransferase-3A (DNMT3A) to promote base excision repair and suppress oxidized DNA. Moreover, they provide evidence that DNMT3A enabled tissue repair in the context of plaque regression in a mouse model of atherosclerosis. Human studies have linked\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    mutation\u2013mediated clonal hematopoiesis (DNMT3A-CH) with atherosclerosis. The findings of Avrampou et al. linking DNMT3A function to efferocytosis-mediated tissue repair suggest that this pathway could be modulated therapeutically to minimize cardiovascular events in patients.\n                  <\/jats:p>","DOI":"10.1172\/jci211265","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:54:47Z","timestamp":1792004087000},"source":"Crossref","is-referenced-by-count":0,"title":["Resolving the links between efferocytosis and DNMT3A mutation\u2013driven clonal hematopoiesis in atherosclerosis"],"prefix":"10.1172","volume":"136","author":[{"given":"Aarti","family":"Asnani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1276"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97947"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0240-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12859"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00551-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701719"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00326-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062126"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.06.022"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI203265"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317104"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43003-w"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.032"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/211265\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:56:08Z","timestamp":1792004168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/211265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":14,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2026,10,15]]},"published-print":{"date-parts":[[2026,10,15]]}},"alternative-id":["10.1172\/JCI211265"],"URL":"https:\/\/doi.org\/10.1172\/jci211265","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"article-number":"e211265"}}