{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:04:12Z","timestamp":1790802252963,"version":"4.1.0"},"reference-count":82,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2008,2,1]]},"DOI":"10.1172\/jci33296","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T17:18:09Z","timestamp":1217956689000},"page":"403-408","source":"Crossref","is-referenced-by-count":132,"title":["Cholesterol in islet dysfunction and type 2 diabetes"],"prefix":"10.1172","volume":"118","author":[{"given":"Liam R.","family":"Brunham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine K.","family":"Kruit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Bruce","family":"Verchere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1172\/JCI105685","volume":"46","author":"Perley","year":"1967","journal-title":"J. Clin. Invest."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4047"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.102"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.3.624"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29103"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/11905"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/11921"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/11914"},{"key":"B9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.7326\/0003-4819-93-2-261","volume":"93","author":"Schaefer","year":"1980","journal-title":"Ann. Intern. Med."},{"key":"B10","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI10727","volume":"106","author":"Clee","year":"2000","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07277-X"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nm1546"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0406"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523915"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27352"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69420-8"},{"key":"B17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI119562","volume":"100","author":"Cavaghan","year":"1997","journal-title":"J. Clin. Invest."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11513"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3547"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073394"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215748"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nm0307-241"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27883"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412564200"},{"key":"B27","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.2337\/diabetes.53.suppl_3.S75","volume":"53(Suppl. 3)","author":"Efanov","year":"2004","journal-title":"Diabetes."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/35035124"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/35035117"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136370"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0133792100"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1142"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2007.jun.S35-S38"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300102200"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220273"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.10.4064"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101419200"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0642-z"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0056"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314314200"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.0162.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2000.011205.x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02906"},{"key":"B45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5551\/jat.13.329","volume":"13","author":"Ishikawa","year":"2006","journal-title":"J. Atheroscler. Thromb."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409706200"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0905"},{"key":"B48","doi-asserted-by":"crossref","unstructured":"Villarreal-Molina, M.T., et al. 2007. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in the Mexican population. Diabetes. doi:10.2337\/db07-0484.","DOI":"10.2337\/db07-0484"},{"key":"B49","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1371\/journal.pgen.0010083","volume":"1","author":"Brunham","year":"2005","journal-title":"PLoS Genetics."},{"key":"B50","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1161\/01.ATV.20.8.1983","volume":"20","author":"Wang","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.2.185"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nature05616"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142364"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142382"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142358"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.119"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00248-1"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111214"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.06.059"},{"key":"B60","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.2169\/naika.91.2762","volume":"91","author":"Saito","year":"2002","journal-title":"Nippon Naika Gakkai Zasshi."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.066"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.12.3486"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.07.009"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506210200"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400011-JLR200"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2198"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306922200"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078520.89539.77"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00688-8"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4245"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/ng1732"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062418"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30706"},{"key":"B74","doi-asserted-by":"crossref","first-page":"e832","DOI":"10.1371\/journal.pone.0000832","volume":"2","author":"Staiger","year":"2007","journal-title":"PLoS ONE."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061815"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.12.008"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511163332001"},{"key":"B78","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.CIR.103.3.357","volume":"103","author":"Freeman","year":"2001","journal-title":"Circulation."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61343-9"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13636-7"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12948-0"},{"key":"B82"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/33296\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:06:31Z","timestamp":1691082391000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/33296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1172\/jci33296","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2,1]]}}}