{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:18:51Z","timestamp":1790065131070,"version":"4.0.1"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[1999,4,15]]},"DOI":"10.1172\/jci5017","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T17:44:11Z","timestamp":1203356651000},"page":"1169-1178","source":"Crossref","is-referenced-by-count":253,"title":["Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria"],"prefix":"10.1172","volume":"103","author":[{"given":"Joachim","family":"Pietz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Kreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertan","family":"Mayatepek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietz","family":"Rating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Joachim","family":"Bremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1203\/00006450-198611000-00010","volume":"20","author":"Krause","year":"1986","journal-title":"Pediatr Res"},{"key":"B2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI111695","volume":"75","author":"Krause","year":"1985","journal-title":"J Clin Invest"},{"key":"B3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1469-8749.1993.tb11552.x","volume":"35","author":"Pietz","year":"1993","journal-title":"Dev Med Child Neurol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0140-6736(85)90250-8","volume":"2","author":"Lou","year":"1985","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1001\/archpedi.1990.02150290033020","volume":"144","author":"Berry","year":"1990","journal-title":"Am J Dis Child"},{"key":"B6","journal-title":""},{"key":"B7","journal-title":""},{"key":"B8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1203\/00006450-199502000-00020","volume":"37","author":"Novotny","year":"1995","journal-title":"Pediatr Res"},{"key":"B9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/jmrb.1995.1084","volume":"107","author":"Kreis","year":"1995","journal-title":"J Magn Reson B"},{"key":"B10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0079-6565(97)00014-9","volume":"31","author":"Kreis","year":"1997","journal-title":"Prog NMR Spectroscopy"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199511000-00005","volume":"38","author":"Pietz","year":"1995","journal-title":"Pediatr Res"},{"key":"B12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1086\/301920","volume":"63","author":"Guldberg","year":"1998","journal-title":"Am J Hum Genet"},{"key":"B13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF01799751","volume":"5","author":"Lutz","year":"1982","journal-title":"J Inherit Metab Dis"},{"key":"B14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1148\/radiology.201.2.8888233","volume":"201","author":"Pietz","journal-title":"Radiology"},{"key":"B15","journal-title":""},{"key":"B16","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1471-4159.1985.tb07209.x","volume":"45","author":"Miller","year":"1985","journal-title":"J Neurochem"},{"key":"B17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mrm.1910390607","volume":"39","author":"Slotboom","year":"1998","journal-title":"Magn Reson Med"},{"key":"B18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1023\/A:1022482604276","volume":"23","author":"Pardridge","year":"1998","journal-title":"Neurochem Res"},{"key":"B19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0005-2736(75)90347-8","volume":"401","author":"Pardridge","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"B20","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/j.1471-4159.1987.tb01039.x","volume":"49","author":"Smith","year":"1987","journal-title":"J Neurochem"},{"key":"B21","doi-asserted-by":"crossref","first-page":"19392","DOI":"10.1016\/S0021-9258(19)77645-5","volume":"263","author":"Hargreaves","year":"1988","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF02391190","volume":"6","author":"Herrero","year":"1983","journal-title":"J Inherit Metab Dis"},{"key":"B23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/jcbfm.1990.123","volume":"10","author":"Knudsen","year":"1990","journal-title":"J Cereb Blood Flow Metab"},{"key":"B24","journal-title":""},{"key":"B25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/BF02436753","volume":"18","author":"Knudsen","year":"1995","journal-title":"J Inherit Metab Dis"},{"key":"B26","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1046\/j.1471-4159.1995.64031252.x","volume":"64","author":"Shulkin","year":"1995","journal-title":"J Neurochem"},{"key":"B27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0006-8993(97)01054-8","volume":"778","author":"M\u00f6ller","year":"1997","journal-title":"Brain Res"},{"key":"B28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00004647-199605000-00009","volume":"16","author":"Gruetter","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"B29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00966321","volume":"3","author":"Hughes","year":"1978","journal-title":"Neurochem Res"},{"key":"B30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/bj2060407","volume":"206","author":"Binek-Singer","year":"1982","journal-title":"Biochem J"},{"key":"B31","journal-title":""},{"key":"B32","journal-title":""},{"key":"B33","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2307\/1130832","volume":"61","author":"Welsh","year":"1990","journal-title":"Child Dev"},{"key":"B34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1651-2227.1954.tb04000.x","volume":"43","author":"Bickel","year":"1954","journal-title":"Acta Paediatr Scand"},{"key":"B35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/adc.68.3.426","volume":"68","year":"1993","journal-title":"Arch Dis Child"},{"key":"B36","first-page":"670","volume":"141","author":"Weglage","year":"1993","journal-title":"Monatsschr Kinderheilkd"},{"key":"B37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1542\/peds.99.3.345","volume":"99","author":"Pietz","year":"1997","journal-title":"Pediatrics"},{"key":"B38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3476(95)70031-5","volume":"127","author":"Pietz","year":"1995","journal-title":"J Pediatr"},{"key":"B39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1203\/00006450-198209000-00009","volume":"16","author":"Berry","year":"1982","journal-title":"Pediatr Res"},{"key":"B40","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1203\/00006450-198906000-00002","volume":"25","author":"Vorhees","year":"1989","journal-title":"Pediatr Res"},{"key":"B41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF01805529","volume":"12","author":"Hommes","year":"1989","journal-title":"J Inherit Metab Dis"},{"key":"B42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01805567","volume":"5(Suppl. 2)","author":"Pratt","year":"1982","journal-title":"J Inherit Metab Dis"},{"key":"B43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00711746","volume":"18","author":"Dotremont","year":"1995","journal-title":"J Inherit Metab Dis"},{"key":"B44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0006-2944(85)90008-0","volume":"33","author":"Huether","year":"1985","journal-title":"Biochem Med"},{"key":"B45","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(94)70360-4","volume":"124","author":"Ris","year":"1994","journal-title":"J Pediatr"},{"key":"B46","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1007\/PL00014226","volume":"155(Suppl. 1)","author":"M\u00f6nch","year":"1996","journal-title":"Eur J Pediatr"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/5017\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:08:47Z","timestamp":1691068127000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/5017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,15]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,4,15]]}},"URL":"https:\/\/doi.org\/10.1172\/jci5017","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4,15]]}}}