{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:46:37Z","timestamp":1791135997585,"version":"4.1.0"},"reference-count":36,"publisher":"American Society for Clinical Investigation","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[1999,4,1]]},"DOI":"10.1172\/jci5342","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T22:47:18Z","timestamp":1203374838000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":426,"title":["Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury"],"prefix":"10.1172","volume":"103","author":[{"given":"Leo E.","family":"Otterbein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K.","family":"Kolls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin L.","family":"Mantell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine M.K.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.15.1.8679227","volume":"15","author":"Choi","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"Maines","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1432-1033.1997.00725.x","volume":"247","author":"McCoubrey","year":"1997","journal-title":"Eur J Biochem"},{"key":"B4","first-page":"410","volume":"75","author":"Tenhunen","year":"1970","journal-title":"J Lab Clin Med"},{"key":"B5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1073\/pnas.86.1.99","volume":"86","author":"Keyse","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"B6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1165\/ajrcmb.14.6.8652184","volume":"14","author":"Lee","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B7","first-page":"974","volume":"51","author":"Applegate","year":"1991","journal-title":"Cancer Res"},{"key":"B8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1172\/JCI115847","volume":"90","author":"Nath","year":"1992","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1165\/ajrcmb.13.5.7576696","volume":"13","author":"Otterbein","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.1073\/pnas.92.15.6798","volume":"92","author":"Abraham","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"B11","doi-asserted-by":"crossref","first-page":"10393","DOI":"10.1073\/pnas.93.19.10393","volume":"93","author":"Lee","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"B12","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1073\/pnas.82.23.7865","volume":"82","author":"Shibahara","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"B13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/0-89603-178-0:109","volume":"7","author":"Graham","year":"1991","journal-title":"Gene transfer and expression protocols"},{"key":"B14","doi-asserted-by":"crossref","first-page":"25129","DOI":"10.1016\/S0021-9258(19)74015-0","volume":"267","author":"Gomez-Foix","year":"1992","journal-title":"J Biol Chem"},{"key":"B15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/hum.1996.7.2-215","volume":"7","author":"Fallaux","year":"1996","journal-title":"Hum Gene Ther"},{"key":"B16","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0042-6822(88)90302-9","volume":"163","author":"McGrory","year":"1988","journal-title":"Virology"},{"key":"B17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1073\/pnas.91.1.215","volume":"91","author":"Kolls","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"B18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1165\/ajrcmb.13.4.7546768","volume":"13","author":"Camhi","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B19","first-page":"L268","volume":"272","author":"Otterbein","year":"1997","journal-title":"Am J Physiol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/sj.cdd.4400278","volume":"4","author":"Mantell","year":"1997","journal-title":"Cell Death Differ"},{"key":"B21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1164\/ajrccm.150.1.8025736","volume":"150","author":"Steinberg","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"B22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/ajrcmb.13.1.7598940","volume":"13","author":"Choi","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B23","first-page":"L14","volume":"275","author":"Otterbein","year":"1998","journal-title":"Am J Physiol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1073\/pnas.91.7.2607","volume":"91","author":"Vile","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"B25","doi-asserted-by":"crossref","first-page":"14678","DOI":"10.1016\/S0021-9258(18)82386-9","volume":"268","author":"Vile","year":"1994","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","volume":"94","author":"Poss","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"B27","doi-asserted-by":"crossref","first-page":"L836","DOI":"10.1152\/ajpcell.1998.275.2.C440","volume":"275","author":"Wong","year":"1998","journal-title":"Am J Physiol"},{"key":"B28","first-page":"L582","volume":"18","author":"Taylor","year":"1998","journal-title":"Am J Physiol"},{"key":"B29","first-page":"L1","volume":"276","author":"Otterbein","year":"1999","journal-title":"Am J Physiol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","volume":"2","author":"Willis","year":"1996","journal-title":"Nat Med"},{"key":"B31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/2063","volume":"4","author":"Soares","year":"1998","journal-title":"Nat Med"},{"key":"B32","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"B33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0167-4889(94)90067-1","volume":"1223","author":"Llesuy","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"B34","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1073\/pnas.92.7.2568","volume":"92","author":"Kharitonov","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"B35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/bmme.1997.2610","volume":"61","author":"Marilena","year":"1997","journal-title":"Biochem Mol Med"},{"key":"B36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.7678352","volume":"259","author":"Verma","year":"1993","journal-title":"Science"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/5342\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:09:11Z","timestamp":1691082551000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/5342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1172\/jci5342","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4,1]]}}}