{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:47:22Z","timestamp":1790286442219,"version":"4.1.0"},"reference-count":65,"publisher":"American Society for Clinical Investigation","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2015,6,1]]},"DOI":"10.1172\/jci59987","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T22:00:06Z","timestamp":1430085606000},"page":"2279-2292","source":"Crossref","is-referenced-by-count":46,"title":["Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease"],"prefix":"10.1172","volume":"125","author":[{"given":"Adel","family":"Ersek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Antonopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry D.","family":"Butters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Espirito","family":"Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youridies","family":"Vattakuzhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Goudevenou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynett","family":"Danks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Freidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Spanoudakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papaioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evdoxia","family":"Hatjiharissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Chaidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic S.","family":"Alonzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Twigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Dwek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Haslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Rahemtulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Horwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Karadimitris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2004.03.007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1267-7_24"},{"key":"B3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0300-9084(03)00006-3","volume":"85","author":"Birkle","year":"2003","journal-title":"Biochimie."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212626200"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000018018.29488.c6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209416"},{"key":"B7","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0022-2275(20)30472-7","volume":"43","author":"Garofalo","year":"2002","journal-title":"J Lipid Res."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.3.782"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.11.6433"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0212"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110994"},{"key":"B12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/bonekey.2012.46","volume":"1","author":"Teti","year":"2012","journal-title":"Bonekey Rep."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282855"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm1417"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.016"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-093294"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104464200"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.05.035"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.05.027"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0121-6"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.08.006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.01.027"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.06.029"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500175049"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04561.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3349"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13116"},{"key":"B29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1182\/blood.V96.2.671","volume":"96","author":"Choi","year":"2000","journal-title":"Blood."},{"key":"B30","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/leu.2009.130","volume":"23","author":"Roussou","year":"2009","journal-title":"Leukemia."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwi076"},{"key":"B32","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1016\/S0021-9258(17)37202-2","volume":"269","author":"Platt","year":"1994","journal-title":"J Biol Chem."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.12.099"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M010819"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.07.018"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80232-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.10.1787"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.05.005"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.11.007"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00369-6"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051150"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwm024"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490607"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060610"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070748"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002353"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-077685"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0121"},{"key":"B49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1026576804247","volume":"17","author":"Kasahara","year":"2000","journal-title":"Glycoconj J."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051189"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.092"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025902113005"},{"key":"B53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fendo.2012.00106","volume":"3","author":"Ersek","year":"2012","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B54","first-page":"5850","volume":"63","author":"Tai","year":"2003","journal-title":"Cancer Res."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-081240"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.6.1271"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.8.1015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1122"},{"key":"B59","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1182\/blood.V64.2.534.534","volume":"64","author":"Nojiri","year":"1984","journal-title":"Blood."},{"key":"B60","first-page":"6100","volume":"45","author":"Nojiri","year":"1985","journal-title":"Cancer Research."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.03.051"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2000.4678"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B64","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1182\/blood-2007-03-082800","volume":"111","author":"Lymperi","year":"2008","journal-title":"Blood."},{"key":"B65","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/59987\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:12:29Z","timestamp":1691082749000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/59987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1172\/jci59987","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}