{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:46:12Z","timestamp":1792820772968,"version":"4.5.0"},"reference-count":135,"publisher":"American Society for Clinical Investigation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2012,9,4]]},"DOI":"10.1172\/jci60047","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T08:02:06Z","timestamp":1346745726000},"page":"3035-3043","source":"Crossref","is-referenced-by-count":1066,"title":["Mechanisms of thyroid hormone action"],"prefix":"10.1172","volume":"122","author":[{"given":"Gregory A.","family":"Brent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0019"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01733.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0424"},{"key":"B5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tem.2009.11.004","volume":"21","author":"Liu","year":"2010","journal-title":"Trends Endocrinol Metab."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32832ff218"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1795"},{"key":"B9","unstructured":"Brent GA Koenig RJ Thyroid and antithyroid drugs. In: Brunton L, Chabner B, Knollman B, eds. Goodman & Gilman\u2019s The Pharmacological Basis of Therapeutics. 12th ed. New York, New York, USA: McGraw-Hill Professional; 2010 1129 1161"},{"key":"B10","doi-asserted-by":"crossref","unstructured":"Tata JR The road to nuclear receptors of thyroid hormone [published online ahead of print March 17, 2012]. Biochim Biophys Acta. doi: 10.1016\/j.bbagen.2012.02.017 .","DOI":"10.1016\/j.bbagen.2012.02.017"},{"key":"B11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2006.01.007","volume":"17","author":"Furlow","year":"2006","journal-title":"Trends Endocrinol Metab."},{"key":"B12","doi-asserted-by":"crossref","unstructured":"Brent GA Davies TF Hypothyroidism and thyroiditis. In: Melmed SP, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 10th ed. Philadelphia, Pennsylvania, USA: Elsevier; 2012 406 439","DOI":"10.1016\/B978-1-4377-0324-5.00013-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2007.04.004"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010056202122"},{"key":"B15","first-page":"1135","volume":"11","author":"Webb","year":"2010","journal-title":"Curr Opin Investig Drugs."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.1.38"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0095"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804604105"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207264200"},{"key":"B20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mce.2009.11.010","volume":"319","author":"Phan","year":"2010","journal-title":"Mol Cell Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0102"},{"key":"B23","first-page":"829","volume":"76","author":"Davis","year":"2011","journal-title":"Steroids."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0093"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor862"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0836"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2741\/s156"},{"key":"B28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI200112584","volume":"108","author":"Ribeiro","year":"2001","journal-title":"J Clin Invest."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0667"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306120200"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.058"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.016"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.4.462"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.24.14274"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0202"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610700200"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0101"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/me.7.10.1319"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0025"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.04.007"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0490"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1104"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0652"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5267-09.2010"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0419"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.231"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.3.1068"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1130"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0235"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-1073"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0397"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/ng1654"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300909200"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17226-7"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1086\/380999"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42113"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1633"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1372"},{"key":"B59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MED.0b013e32834a78b3","volume":"18","author":"Bernal","year":"2011","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2750"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1014"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0209"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-27-2-279"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2007.03.005"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8977"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01031.x"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110296"},{"key":"B68","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMc1113940","volume":"366","author":"van Mullem","year":"2012","journal-title":"N Engl J Med."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.6.2299"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2642"},{"key":"B71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg2736","volume":"11","author":"Perissi","year":"2010","journal-title":"Nat Rev Genet."},{"key":"B72","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1043-2760(99)00215-5","volume":"11","author":"Hu","year":"2000","journal-title":"Trends Endocrinol Metab."},{"key":"B73","first-page":"329","volume":"1","author":"Brent","year":"1989","journal-title":"New Biol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1329"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062413299"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1530\/JME-10-0163"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.09.016"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0462"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107474108"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0093"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0501"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0174"},{"key":"B83","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.1152\/ajpendo.00226.2002","volume":"284","author":"Sadow","year":"2003","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.7.1900"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0373"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.03.006"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509981103"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832a2c63"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.06.021"},{"key":"B90","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tem.2011.11.002","volume":"23","author":"Waung","year":"2012","journal-title":"Trends Endocrinol Metab."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1210\/me.8.6.746"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0751"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.10.1527"},{"key":"B94","first-page":"749","volume":"9","author":"Gandrillon","year":"1994","journal-title":"Oncogene."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0210"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8872"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.7.2664"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211117"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16391"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1210\/me.2001-0324"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0958"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0567"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.123158"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0175"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.03.010"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-161802"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.016"},{"key":"B108","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tem.2009.11.008","volume":"21","author":"Fliers","year":"2010","journal-title":"Trends Endocrinol Metab."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38793"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508556102"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0150"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507877200"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006162107"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.04.001"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.2100.com1"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905633"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.9.3057"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1325"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702759104"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1329"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.834424"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1209"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788803277"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.04.014"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90544-9"},{"key":"B126","first-page":"215","volume":"6","author":"Gandrillon","year":"1995","journal-title":"Int J Oncol."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0420"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.11.005"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0425"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2008.10.009"},{"key":"B131","first-page":"885","volume":"76","author":"Lu","year":"2011","journal-title":"Steroids."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.1.124-135.2005"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.8.3204-3214.2006"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706754104"},{"key":"B135","doi-asserted-by":"crossref","first-page":"E1135","DOI":"10.1152\/ajpendo.00506.2002","volume":"285","author":"Freitas","year":"2003","journal-title":"Am J Physiol Endocrinol Metab."}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/60047\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:12:33Z","timestamp":1691068353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/60047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":135,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9,4]]}},"URL":"https:\/\/doi.org\/10.1172\/jci60047","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}