{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:07:01Z","timestamp":1791227221134,"version":"4.1.0"},"reference-count":75,"publisher":"American Society for Clinical Investigation","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2014,3,3]]},"DOI":"10.1172\/jci72094","type":"journal-article","created":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T06:00:20Z","timestamp":1392530420000},"page":"1393-1405","source":"Crossref","is-referenced-by-count":399,"title":["Bitter and sweet taste receptors regulate human upper respiratory innate immunity"],"prefix":"10.1172","volume":"124","author":[{"given":"Robert J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Kofonow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Doghramji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kreindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Margolskee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam A.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.004"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425910365734"},{"key":"B3","first-page":"1","volume":"328","author":"Cherry","year":"2002","journal-title":"Adv Data."},{"key":"B4","first-page":"1","author":"Blackwell","year":"2002","journal-title":"Vital Health Stat."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70464-1"},{"key":"B6","first-page":"1","volume":"327","author":"Ly","year":"2002","journal-title":"Adv Data."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.08.006"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3911"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173869"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64240"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911934107"},{"key":"B12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4193\/Rhino.11.121","volume":"49","author":"Braun","year":"2011","journal-title":"Rhinology."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21149"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-3"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.02.010"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjp092"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00066.2008"},{"key":"B18","first-page":"203","volume":"47","author":"Behrens","year":"2009","journal-title":"Results Probl Cell Differ."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2010.0334"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.130454"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1531172100"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.04.011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/26.3.259"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705641200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414287200"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2174\/138161206779010350"},{"key":"B27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbrc.2010.05.088","volume":"397","author":"Imada","year":"2010","journal-title":"Biochem Biophys Res Commun."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040304"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2144\/000112531"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200810017"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-234476"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100054200"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20172"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004278200"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1042\/BST0310954"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66182"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2500\/105065801779954238"},{"key":"B38","doi-asserted-by":"crossref","first-page":"L799","DOI":"10.1152\/ajplung.2000.279.5.L799","volume":"279","author":"Singh","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2410"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2011.04.003"},{"key":"B41","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4193\/Rhino11.072","volume":"49","author":"Thienhaus","year":"2011","journal-title":"Rhinology."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0011RT"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3025"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3127"},{"key":"B45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4193\/Rhin11.229","volume":"50","author":"Woods","year":"2012","journal-title":"Rhinology."},{"key":"B46","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1183\/09031936.00052612","volume":"40","author":"Garnett","year":"2012","journal-title":"Eur Respir J."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0576-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0459-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016166"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.035766"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01425.2006"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200718"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.052"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20014"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054500"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/24.4.439"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072090199"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706890104"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115183109"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr755"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjq027"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2903"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21081"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3032"},{"key":"B65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0891-5520(20)30641-3","volume":"9","author":"Koziel","year":"1995","journal-title":"Infect Dis Clin North Am."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.090"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00344.2007"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.001"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3034"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-120"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00102.2011"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.2144\/000112531"},{"key":"B73","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2818.2003.01209.x","volume":"211","author":"Sisson","year":"2003","journal-title":"J Microsc."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030333"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1961-2"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/72094\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:26:06Z","timestamp":1691069166000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/72094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,17]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3,3]]}},"URL":"https:\/\/doi.org\/10.1172\/jci72094","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718278161.793491372","asserted-by":"object"}]},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,17]]}}}