{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:31:41Z","timestamp":1788496301460,"version":"build-2803163510"},"reference-count":66,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,19]]},"DOI":"10.1172\/jci81928","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T18:00:48Z","timestamp":1453140048000},"page":"667-680","source":"Crossref","is-referenced-by-count":58,"title":["CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders"],"prefix":"10.1172","volume":"126","author":[{"given":"Xiuying","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengshun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"St-Arnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Petkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goltzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Karaplis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0887-1_3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101545198"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.02.027"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207872200"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210490200"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32409"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0233"},{"issue":"4","key":"B8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1210\/endo.134.4.8137741","article-title":"Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets","volume":"134","author":"Roy","year":"1994","journal-title":"Endocrinology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0243"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-130"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119276"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5372"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020028"},{"issue":"7","key":"B14","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/endo.141.7.7579","article-title":"Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D","volume":"141","author":"St-Arnaud","year":"2000","journal-title":"Endocrinology"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.3.434"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00064.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000305"},{"issue":"3","key":"B18","first-page":"229","article-title":"FGF23 promotes renal calcium reabsorption through the TRPV5 channel","volume":"33","author":"Andrukhova","year":"2014","journal-title":"EMBO J"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2008.6.2.68"},{"issue":"7 suppl","key":"B20","doi-asserted-by":"crossref","first-page":"1971S","DOI":"10.1093\/jn\/125.suppl_7.1971S","article-title":"Vitamin D and intestinal calcium transport: facts, speculations and hypotheses","volume":"125","author":"Wasserman","year":"1995","journal-title":"J Nutr"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00237.2009"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.7.7557"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300205"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-6-2868"},{"issue":"6 suppl","key":"B25","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113342"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010020186"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0255"},{"issue":"1\u20132","key":"B29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2004.07.012","article-title":"Characterization of vitamin D-mediated induction of the CYP 24 transcription","volume":"226","author":"Tashiro","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4781(95)00060-T","article-title":"Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements","volume":"1263","author":"Chen","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00360.2009"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.05.024"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6374fje"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.298"},{"issue":"10","key":"B35","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/endo.136.10.7664636","article-title":"Human osteoblasts in culture metabolize both 1 alpha, 25-dihydroxyvitamin D3 and its precursor 25-hydroxyvitamin D3 into their respective lactones","volume":"136","author":"Siu-Caldera","year":"1995","journal-title":"Endocrinology"},{"issue":"15","key":"B36","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1016\/S0021-9258(18)43337-6","article-title":"Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3","volume":"256","author":"Howard","year":"1981","journal-title":"J Biol Chem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-1075com"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.08.008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.012"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.11.6433"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2081"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00023-1"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1410"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29463"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0113"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107707200"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050212"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9201-y"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0250001"},{"issue":"3","key":"B50","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0039-128X(00)00229-4","article-title":"Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D(3): CYP27 in epidermis completes the set of essential vitamin D(3)-hydroxylases","volume":"66","author":"Schuessler","year":"2001","journal-title":"Steroids"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1156"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4119"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005111185"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020881"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111900"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112263252604"},{"issue":"4-5","key":"B57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02405074","article-title":"Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets","volume":"35","author":"Marie","year":"1983","journal-title":"Calcif Tissue Int"},{"issue":"8668","key":"B58","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0140-6736(89)91559-6","article-title":"Hypophosphataemic rickets: final height and clinical symptoms in adults","volume":"2","author":"Stickler","year":"1989","journal-title":"Lancet"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1810"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1831"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72829"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408903200"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1671"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1695"},{"issue":"2","key":"B65","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1210\/endo.142.2.7976","article-title":"Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition","volume":"142","author":"Miao","year":"2001","journal-title":"Endocrinology"},{"key":"B66","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-3-16","article-title":"Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo","volume":"3","author":"Miao","year":"2002","journal-title":"BMC Musculoskelet Disord"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/81928\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:50:33Z","timestamp":1691070633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/81928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,1]]}},"alternative-id":["10.1172\/JCI81928"],"URL":"https:\/\/doi.org\/10.1172\/jci81928","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726084489.793519542","asserted-by":"object"}]},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}