{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:31Z","timestamp":1791328771328,"version":"4.3.1"},"reference-count":44,"publisher":"American Society for Clinical Investigation","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"DOI":"10.1172\/jci82249","type":"journal-article","created":{"date-parts":[[2015,9,13]],"date-time":"2015-09-13T22:01:24Z","timestamp":1442181684000},"page":"3941-3951","source":"Crossref","is-referenced-by-count":46,"title":["Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients"],"prefix":"10.1172","volume":"125","author":[{"given":"Francesca","family":"Pala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Morbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmina","family":"Castiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Nicolas","family":"Schickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Scaramuzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"Glauzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Romberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Candotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Aiuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Bosticardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Meffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-115253"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2724"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1480"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00209","article-title":"Autoimmunity in Wiskott-Aldrich syndrome: an unsolved enigma","volume":"3","author":"Catucci","year":"2012","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061334"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061338"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.02.001"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29539"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110200"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379412"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.030"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199805)185:1<99::AID-PATH48>3.0.CO;2-L"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.037"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.10.006"},{"issue":"6 pt 1","key":"B15","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0022-3476(05)82002-5","article-title":"A multiinstitutional survey of the Wiskott-Aldrich syndrome","volume":"125","author":"Sullivan","year":"1994","journal-title":"J Pediatr"},{"key":"B16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/TACG.S58444","article-title":"Wiskott-Aldrich syndrome: diagnosis, current management, and emerging treatments","volume":"7","author":"Buchbinder","year":"2014","journal-title":"Appl Clin Genet"},{"issue":"3","key":"B17","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jaci.2013.08.050","article-title":"Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome","volume":"133","author":"Simon","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243071"},{"issue":"9","key":"B19","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1182\/blood.V78.9.2372.2372","article-title":"Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens","volume":"78","author":"Silberstein","year":"1991","journal-title":"Blood"},{"issue":"12","key":"B20","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.4049\/jimmunol.146.12.4385","article-title":"Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype","volume":"146","author":"Pascual","year":"1991","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040920"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.015"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69854"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06347.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457465"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062287"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.051"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.042"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233151"},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.01.035","article-title":"B cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome","author":"Castiello","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2305"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/art.37828"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102022"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102600108"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-366781"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120363"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00943.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.07.016"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-322834"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1658"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.006"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7451"},{"issue":"1","key":"B44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.20031550","article-title":"Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies","volume":"199","author":"Meffre","year":"2004","journal-title":"J Exp Med"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/82249\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T01:34:31Z","timestamp":1691976871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/82249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,14]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,9,14]]},"published-print":{"date-parts":[[2015,10,1]]}},"alternative-id":["10.1172\/JCI82249"],"URL":"https:\/\/doi.org\/10.1172\/jci82249","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9,14]]}}}