{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:14:55Z","timestamp":1791616495019,"version":"4.3.4"},"reference-count":52,"publisher":"American Society for Clinical Investigation","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,23]]},"DOI":"10.1172\/jci82534","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T23:00:52Z","timestamp":1448233252000},"page":"68-84","source":"Crossref","is-referenced-by-count":163,"title":["Antisense oligonucleotide\u2013mediated MDM4 exon 6 skipping impairs tumor growth"],"prefix":"10.1172","volume":"126","author":[{"given":"Michael","family":"Dewaele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Tabaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Willekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun Xie","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana H.P.","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl M.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rambow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljosja","family":"Rogiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Radaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthafar","family":"Al-Haddawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Amant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnacaram Chandrahas","family":"Koumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Thye","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Derheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Bonday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Tergaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Shackleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Marine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Guccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.151"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00330-10"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013656"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401973"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508500103"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1101\/gad.16722111"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2009.03.001"},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.33","article-title":"p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53","volume":"6","author":"Yan","year":"2015","journal-title":"Cell Death Dis"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5835-5843.2004"},{"issue":"12","key":"B10","first-page":"909","article-title":"Regulating the p53 pathway: in vitro hypotheses, in vivo veritas","volume":"6","author":"Toledo","year":"2006","journal-title":"Cancer"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3430"},{"key":"B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-12-380916-2.00003-6","article-title":"MDM2 and MDMX in cancer and development","volume":"94","author":"Marine","year":"2011","journal-title":"Curr Top Dev Biol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2863"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002011"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nature09626"},{"issue":"4","key":"B17","first-page":"1493","article-title":"New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies","volume":"34","author":"Azijli","year":"2014","journal-title":"Anticancer Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.27"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.19.6797"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01108-07"},{"issue":"5","key":"B21","first-page":"492","article-title":"High levels of Hdmx promote cell growth in a subset of uveal melanomas","volume":"2","author":"de Lange","year":"2012","journal-title":"Am J Cancer Res"},{"issue":"3","key":"B22","first-page":"153","article-title":"Alternative splicing: a pivotal step between eukaryotic transcription and translation","volume":"14","author":"Kornblihtt","year":"2013","journal-title":"Mol Cell Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.02.029"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1101\/gad.247361.114"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8299"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1101\/gad.219899.113"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.230"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1431692100"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0215"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-3-r17"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.03.001"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.029"},{"key":"B33","article-title":"Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation","volume":"3","author":"Liu","year":"2013","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.041"},{"issue":"7","key":"B35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nbt.1873","article-title":"Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data","volume":"29","author":"Zhang","year":"2011","journal-title":"Nat Biotechnol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.027"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314298200"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377218"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60284-X"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1288"},{"issue":"3","key":"B41","article-title":"BRAF, MEK and KIT inhibitors for melanoma: adverse events and their management","volume":"3","author":"Livingstone","year":"2014","journal-title":"Chin Clin Oncol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.522"},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.1038\/srep07545","article-title":"Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer","volume":"4","author":"Shi","year":"2014","journal-title":"Sci Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.266361"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/876173","article-title":"Functions of MDMX in the modulation of the p53-response","volume":"2011","author":"Lenos","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-013-0407-z"},{"issue":"7","key":"B47","doi-asserted-by":"crossref","first-page":"806","DOI":"10.7150\/ijbs.6.806","article-title":"SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance","volume":"6","author":"Jia","year":"2010","journal-title":"Int J Biol Sci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1253408"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2174\/138945008784911796"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjr030"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.288"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0042-2"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/82534\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:50:49Z","timestamp":1691085049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/82534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,23]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,4]]}},"alternative-id":["10.1172\/JCI82534"],"URL":"https:\/\/doi.org\/10.1172\/jci82534","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,23]]}}}