{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:15:01Z","timestamp":1790010901538,"version":"4.0.1"},"reference-count":58,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,11]]},"DOI":"10.1172\/jci82670","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T23:00:37Z","timestamp":1452466837000},"page":"627-638","source":"Crossref","is-referenced-by-count":66,"title":["Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease"],"prefix":"10.1172","volume":"126","author":[{"given":"Jos\u00e9 R.","family":"Naranjo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xose M.","family":"Dopazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mor\u00f3n-Oset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Higueras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Arrabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Cerc\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"De la Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Casado-Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"R\u00e1bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gutierrez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.66"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.04.013"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23282"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.534743"},{"issue":"4","key":"B5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/nan.12211","article-title":"Modulating the unfolded protein response to prevent neurodegeneration enhance memory","volume":"41","author":"Halliday","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3689"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212200-00011"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128294"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.047"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3486"},{"key":"B11","article-title":"Pharmacological brake-release of mRNA translation enhances cognitive memory","volume":"2","author":"Sidrauski","year":"2014","journal-title":"Elife"},{"issue":"206","key":"B12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006767","article-title":"Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice","volume":"5","author":"Moreno","year":"2014","journal-title":"Sci Transl Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.014"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.9.1259"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl013"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/18044"},{"issue":"7","key":"B17","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1089\/ars.2010.3385","article-title":"Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM","volume":"14","author":"Rivas","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/35000592"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/2673"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00360-13"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3912-05.2005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.384982"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.196972"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2493"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1312-10.2010"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1186\/1756-6606-3-3","article-title":"DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory","volume":"3","author":"Wu","year":"2010","journal-title":"Mol Brain"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00629-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600810"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2799"},{"issue":"10","key":"B31","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993","article-title":"Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid","volume":"13","author":"Beal","year":"1993","journal-title":"J Neurosci"},{"issue":"pt 1","key":"B32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/bj20030376","article-title":"Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide","volume":"375","author":"Okada","year":"2003","journal-title":"Biochem J"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.06.042"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2357-z"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1210"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf440"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500338200"},{"issue":"35","key":"B38","doi-asserted-by":"crossref","first-page":"27013","DOI":"10.1016\/S0021-9258(19)61473-0","article-title":"Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response","volume":"275","author":"Wang","year":"2000","journal-title":"J Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00611-0"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00022-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.018"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.018325"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.11.3787"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.50.33741"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn040"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.18.6755-6767.2000"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00681-7"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi053"},{"issue":"5 pt 1","key":"B49","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1525-0016(03)00063-7","article-title":"DNA vaccination against mutant huntingtin ameliorates the HDR6\/2 diabetic phenotype","volume":"7","author":"Miller","year":"2003","journal-title":"Mol Ther"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006534"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000152"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118138109"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1460-04.2004"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gng015"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg405"},{"key":"B56"},{"issue":"1","key":"B57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Statist Soc B"},{"issue":"Web Server issue","key":"B58","doi-asserted-by":"crossref","first-page":"W478","DOI":"10.1093\/nar\/gks402","article-title":"GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics","volume":"40","author":"Tabas-Madrid","year":"2012","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/82670\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T18:34:36Z","timestamp":1718303676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/82670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,1]]}},"alternative-id":["10.1172\/JCI82670"],"URL":"https:\/\/doi.org\/10.1172\/jci82670","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}