{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:45:42Z","timestamp":1791924342419,"version":"4.3.4"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,17]]},"DOI":"10.1172\/jci86504","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T18:00:38Z","timestamp":1476640838000},"page":"4250-4261","source":"Crossref","is-referenced-by-count":174,"title":["mTOR has distinct functions in generating versus sustaining humoral immunity"],"prefix":"10.1172","volume":"126","author":[{"given":"Derek D.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Gaudette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel R.","family":"Wilmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Chernova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bortnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan M.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Allman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.01.011"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.5.1165"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/40540"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80541-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.6.813"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1900"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-200014"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102808"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100783"},{"key":"B10","article-title":"Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection","volume":"7","author":"Bohannon","year":"2016","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.731"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.265"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/328805a0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.757597"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092712"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.2.19022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130030"},{"key":"B18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2013.00165","article-title":"The paradox of Akt-mTOR interactions","volume":"3","author":"Vadlakonda","year":"2013","journal-title":"Front Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.03.029"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103143"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature08155"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn216"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307088289"},{"issue":"3","key":"B25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrrheum.2015.172","article-title":"Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases","volume":"12","author":"Perl","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-477505"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2741"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201767"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407104111"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040677"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040168"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401264"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213368"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.014"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501365"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002163"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nature11083"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.032"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040973"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.022"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6773-6787.2004"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.021"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211209"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075032"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.08.010"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3348"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067752"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/art.27233"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135081"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1132698"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.07.011"},{"issue":"208","key":"B52","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006941","article-title":"Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression","volume":"5","author":"Hassan","year":"2013","journal-title":"Sci Transl Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nature09584"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn224"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/86504\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:53:38Z","timestamp":1691070818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/86504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11,1]]}},"alternative-id":["10.1172\/JCI86504"],"URL":"https:\/\/doi.org\/10.1172\/jci86504","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]}}}