{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:01:37Z","timestamp":1792519297072,"version":"4.5.0"},"reference-count":71,"publisher":"American Society for Clinical Investigation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,2]]},"DOI":"10.1172\/jci86721","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T18:00:38Z","timestamp":1470074438000},"page":"3363-3376","source":"Crossref","is-referenced-by-count":465,"title":["Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells"],"prefix":"10.1172","volume":"126","author":[{"given":"Partow","family":"Kebriaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Helen","family":"Huls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Figliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipulendu","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret J.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pappanaicken R.","family":"Kumaresan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourindra","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branden","family":"Moriarity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Andr\u00e9e","family":"Forget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Senyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rineka N.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy S.","family":"Moyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Rondon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzaffar","family":"Qazilbash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ciurea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Alousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yago","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Rezvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Popat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Hosing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Shpall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wierda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Anh","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Largaespada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry B.","family":"Hackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Champlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence J.N.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"issue":"177","key":"B1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005930","article-title":"CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia","volume":"5","author":"Brentjens","year":"2013","journal-title":"Sci Transl Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008226"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215134"},{"issue":"95","key":"B4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002842","article-title":"T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia","volume":"3","author":"Kalos","year":"2011","journal-title":"Sci Transl Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384388"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2025"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281931"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103849"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61403-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407222"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.24"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.31"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ph8020230"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80436-5"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00099-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5600"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-043737"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0160"},{"issue":"3","key":"B19","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood-2006-05-018192","article-title":"Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12\/ECOG 2993 study","volume":"109","author":"Fielding","year":"2007","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-234492"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-012-0116-3"},{"issue":"9","key":"B22","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1038\/sj.leu.2404824","article-title":"Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial","volume":"21","author":"Tavernier","year":"2007","journal-title":"Leukemia"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.258"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.05.007"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.014"},{"issue":"6","key":"B26","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/leu.2011.351","article-title":"Outcomes and prognostic factors of adults with acute lymphoblastic leukemia who relapse after allogeneic hematopoietic cell transplantation. An analysis on behalf of the Acute Leukemia Working Party of EBMT","volume":"26","author":"Spyridonidis","year":"2012","journal-title":"Leukemia"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12639"},{"issue":"8","key":"B28","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/leu.2010.133","article-title":"Preemptive alloimmune intervention in high-risk pediatric acute lymphoblastic leukemia patients guided by minimal residual disease level before stem cell transplantation","volume":"24","author":"Lankester","year":"2010","journal-title":"Leukemia"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.195"},{"key":"B30","first-page":"S15","article-title":"Graft versus leukemia (GVL) in the therapy of acute lymphoblastic leukemia (ALL)","volume":"11 Suppl 4","author":"Appelbaum","year":"1997","journal-title":"Leukemia"},{"issue":"2","key":"B31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1200\/JCO.1997.15.2.433","article-title":"Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation","volume":"15","author":"Collins","year":"1997","journal-title":"J Clin Oncol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701064"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2009.114"},{"issue":"72","key":"B34","doi-asserted-by":"crossref","DOI":"10.3791\/50070","article-title":"Clinical application of Sleeping Beauty artificial antigen presenting cells to genetically modify T cells from peripheral umbilical cord blood","author":"Huls","year":"2013","journal-title":"J Vis Exp"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3182811ce9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12137"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2014.69"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064138"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030264"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3234"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.167"},{"issue":"11","key":"B42","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1182\/blood.V88.11.4383.4383","article-title":"Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation","volume":"88","author":"Przepiorka","year":"1996","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"issue":"4","key":"B44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/1078155213501360","article-title":"The impact of pre-transplant valganciclovir on early cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation","volume":"20","author":"Wilhelm","year":"2013","journal-title":"J Oncol Pharm Pract"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00295","article-title":"Impact of inflammatory cytokines on effector and memory CD8+ T cells","volume":"5","author":"Kim","year":"2014","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2974"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-128843"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703779"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504542"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000182"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000181"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664250"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.013"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.04.005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-506741"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.5929"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-606939"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.11.019"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46110"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac5415"},{"key":"B61","doi-asserted-by":"crossref","DOI":"10.1186\/1479-5876-9-113","article-title":"Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays","volume":"9","author":"Kim","year":"2011","journal-title":"J Transl Med"},{"key":"B62","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/434010","article-title":"Cytokine levels in the serum of healthy subjects","volume":"2013","author":"Kleiner","year":"2013","journal-title":"Mediators Inflamm"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.208"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.12.005"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201000027"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.03.014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-387969"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2133"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/ng.343"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2641"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.2307\/2529872"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/86721\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:53:42Z","timestamp":1691070822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/86721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":71,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9,1]]}},"alternative-id":["10.1172\/JCI86721"],"URL":"https:\/\/doi.org\/10.1172\/jci86721","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}