{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:11:07Z","timestamp":1789150267074,"version":"build-2803163510"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,19]]},"DOI":"10.1172\/jci87526","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T23:02:36Z","timestamp":1482102156000},"page":"487-499","source":"Crossref","is-referenced-by-count":74,"title":["M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss"],"prefix":"10.1172","volume":"127","author":[{"given":"Sophie J.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie-Myrtille","family":"Bourgognon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Verity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Mogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Macedo-Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Wess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Broad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joern R.","family":"Steinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna R.","family":"Mallucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Felder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802515105"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2174\/157015910790909520"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.6338589"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2168"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000752"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00092-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2379"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1995.1018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature10867"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature10753"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.087551"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550160091022"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.06091591"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.09.009"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702463"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384303"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105159"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.226712"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900903106"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.03.029"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3813-x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4052"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2012.04.001"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.3.202"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1487-z"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090187"},{"issue":"Pt 6","key":"B27","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1099\/vir.0.049619-0","article-title":"Targeted knock-down of cellular prion protein expression in myelinating Schwann cells does not alter mouse prion pathogenesis","volume":"94","author":"Halliez","year":"2013","journal-title":"J Gen Virol"},{"issue":"1","key":"B28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0022-3565(25)38668-4","article-title":"Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708\/NNC11-0232)","volume":"269","author":"Bymaster","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"B29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3565(25)38667-2","article-title":"Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors","volume":"269","author":"Shannon","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.083006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.314278"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1021\/jm400540b"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.604967"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.274"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.681726"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12211"},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.49","article-title":"Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity","volume":"6","author":"Halliday","year":"2015","journal-title":"Cell Death Dis"},{"issue":"2","key":"B38","first-page":"119","article-title":"The role of GPI-anchored PrP C in mediating the neurotoxic effect of scrapie prions in neurons","volume":"12","author":"Radford","year":"2010","journal-title":"Curr Issues Mol Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.519"},{"issue":"5 Pt 2","key":"B40","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1523\/JNEUROSCI.15-05-04077.1995","article-title":"Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation","volume":"15","author":"Levey","year":"1995","journal-title":"J Neurosci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.7046051"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.3992249"},{"issue":"6","key":"B43","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/sj.npp.1300151","article-title":"The muscarinic M1\/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys","volume":"28","author":"Andersen","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00138-3"},{"issue":"2","key":"B45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1527-3458.2003.tb00247.x","article-title":"Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists","volume":"9","author":"Mirza","year":"2003","journal-title":"CNS Drug Rev"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.19"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00401-6"},{"issue":"1\u20132","key":"B48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082915"},{"issue":"27","key":"B50","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1523\/JNEUROSCI.23-27-09220.2003","article-title":"Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells","volume":"23","author":"Seidenman","year":"2003","journal-title":"J Neurosci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00160-4"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211132798"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1215"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2760"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00401","article-title":"The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity","volume":"8","author":"Chater","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.539080"},{"key":"B57","doi-asserted-by":"crossref","unstructured":"Witkin KM, et al. In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2\/3 receptor antagonist [published online ahead of print December 31, 2015]. Neuropharmacology. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.12.021","DOI":"10.1016\/j.neuropharm.2015.12.021"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/87526\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:31:32Z","timestamp":1749839492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/87526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"alternative-id":["10.1172\/JCI87526"],"URL":"https:\/\/doi.org\/10.1172\/jci87526","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}